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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Corticotropin-releasing factor receptor 1 | ||
| Ligand | BDBM50152187 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_303525 (CHEMBL839639) | ||
| Ki | 15±n/a nM | ||
| Citation |  Chen, C; Wilcoxen, KM; Huang, CQ; Xie, YF; McCarthy, JR; Webb, TR; Zhu, YF; Saunders, J; Liu, XJ; Chen, TK; Bozigian, H; Grigoriadis, DE Design of 2,5-dimethyl-3-(6-dimethyl-4-methylpyridin-3-yl)-7-dipropylaminopyrazolo[1,5-a]pyrimidine (NBI 30775/R121919) and structure--activity relationships of a series of potent and orally active corticotropin-releasing factor receptor antagonists. J Med Chem47:4787-98 (2004) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Corticotropin-releasing factor receptor 1 | |||
| Name: | Corticotropin-releasing factor receptor 1 | ||
| Synonyms: | CRF-R | CRF-R2 Alpha | CRF1 | CRFR | CRFR1 | CRFR1_HUMAN | CRH-R 1 | CRHR | CRHR1 | Corticotropin releasing factor receptor 1 | Corticotropin-releasing factor receptor 1 (CRF-1) | Corticotropin-releasing factor receptor 1 (CRF1) | Corticotropin-releasing hormone receptor 1 | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 50744.31 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P34998 | ||
| Residue: | 444 | ||
| Sequence: |
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| BDBM50152187 | |||
| n/a | |||
| Name | BDBM50152187 | ||
| Synonyms: | CHEMBL363269 | [3-(6-Dimethylamino-4-methyl-pyridin-3-yl)-2,5-dimethyl-pyrazolo[1,5-a]pyrimidin-7-yl]-naphthalen-2-ylmethyl-propyl-amine | ||
| Type | Small organic molecule | ||
| Emp. Form. | C30H34N6 | ||
| Mol. Mass. | 478.6312 | ||
| SMILES | CCCN(Cc1ccc2ccccc2c1)c1cc(C)nc2c(c(C)nn12)-c1cnc(cc1C)N(C)C |(6.09,-2.02,;4.59,-1.71,;4.1,-.26,;2.6,.06,;2.11,1.54,;3.13,2.68,;4.64,2.36,;5.67,3.52,;5.19,4.98,;6.2,6.14,;5.71,7.58,;4.19,7.89,;3.16,6.75,;3.66,5.3,;2.64,4.15,;1.57,-1.08,;2.04,-2.53,;1.01,-3.7,;1.5,-5.15,;-.49,-3.39,;-.97,-1.93,;-2.38,-1.31,;-2.22,.23,;-3.38,1.25,;-.72,.56,;.05,-.78,;-3.71,-2.08,;-3.71,-3.63,;-5.05,-4.4,;-6.38,-3.63,;-6.38,-2.09,;-5.05,-1.31,;-5.05,.23,;-7.72,-4.4,;-9.06,-3.63,;-7.72,-5.95,)| | ||
| Structure | 
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