| Reaction Details |
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 | Report a problem with these data |
| Target | Melanin-concentrating hormone receptor 1 |
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| Ligand | BDBM50152504 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_306738 (CHEMBL832325) |
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| IC50 | 41±n/a nM |
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| Citation |  Souers, AJ; Wodka, D; Gao, J; Lewis, JC; Vasudevan, A; Brodjian, S; Dayton, B; Ogiela, CA; Fry, D; Hernandez, LE; Marsh, KC; Collins, CA; Kym, PR Synthesis and evaluation of 2-amino-8-alkoxy quinolines as MCHr1 antagonists. Part 3. Bioorg Med Chem Lett14:4883-6 (2004) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Melanin-concentrating hormone receptor 1 |
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| Name: | Melanin-concentrating hormone receptor 1 |
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| Synonyms: | G-protein coupled receptor 24 | GPR24 | MCH receptor 1 | MCH-1R | MCH-R1 | MCHR | MCHR-1 | MCHR1 | MCHR1_HUMAN | Melanin Concentrating Hormone 1 | Melanin-Concentrating Hormone Receptor 1 (MCH1R) | Melanin-concentrating hormone receptor | Melanin-concentrating hormone receptor 1 (MCH-1) | Melanin-concentrating hormone receptor 1 (MCH1) | Melanin-concentrating hormone receptor 1 (MCHR-1) | Melanin-concentrating hormone receptor 1 (MCHR1) | SLC-1 | SLC1 | Somatostatin receptor-like protein |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 45976.27 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Membranes from CHO-K1 cells stably expressing human MCH1R were used in assays. |
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| Residue: | 422 |
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| Sequence: | MSVGAMKKGVGRAVGLGGGSGCQATEEDPLPNCGACAPGQGGRRWRLPQPAWVEGSSARL
WEQATGTGWMDLEASLLPTGPNASNTSDGPDNLTSAGSPPRTGSISYINIIMPSVFGTIC
LLGIIGNSTVIFAVVKKSKLHWCNNVPDIFIINLSVVDLLFLLGMPFMIHQLMGNGVWHF
GETMCTLITAMDANSQFTSTYILTAMAIDRYLATVHPISSTKFRKPSVATLVICLLWALS
FISITPVWLYARLIPFPGGAVGCGIRLPNPDTDLYWFTLYQFFLAFALPFVVITAAYVRI
LQRMTSSVAPASQRSIRLRTKRVTRTAIAICLVFFVCWAPYYVLQLTQLSISRPTLTFVY
LYNAAISLGYANSCLNPFVYIVLCETFRKRLVLSVKPAAQGQLRAVSNAQTADEERTESK
GT
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| BDBM50152504 |
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| n/a |
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| Name | BDBM50152504 |
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| Synonyms: | CHEMBL185266 | {8-[1-(4-Isobutyl-phenyl)-pyrrolidin-3-yloxy]-quinolin-2-yl}-[5-(3-trifluoromethyl-phenyl)-furan-2-ylmethyl]-amine |
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| Type | Small organic molecule |
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| Emp. Form. | C35H34F3N3O2 |
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| Mol. Mass. | 585.6586 |
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| SMILES | CC(C)Cc1ccc(cc1)N1CCC(C1)Oc1cccc2ccc(NCc3ccc(o3)-c3cccc(c3)C(F)(F)F)nc12 |
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| Structure | 
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