| Reaction Details |
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 | Report a problem with these data |
| Target | Macrophage metalloelastase |
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| Ligand | BDBM50152637 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_302322 (CHEMBL828909) |
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| Ki | >300000±n/a nM |
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| Citation |  Cook, GR; Manivannan, E; Underdahl, T; Lukacova, V; Zhang, Y; Balaz, S Synthesis and evaluation of novel oxazoline MMP inhibitors. Bioorg Med Chem Lett14:4935-9 (2004) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Macrophage metalloelastase |
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| Name: | Macrophage metalloelastase |
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| Synonyms: | HME | MMP12 | MMP12_HUMAN | Matrix metalloproteinase 12 | Matrix metalloproteinase-12 (MMP 12) | Matrix metalloproteinase-12 (MMP-12) | Matrix metalloproteinase-12 (MMP12) | Matrix metalloproteinases 12 (MMP-12) |
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| Type: | Enzyme |
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| Mol. Mass.: | 54012.99 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P39900 |
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| Residue: | 470 |
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| Sequence: | MKFLLILLLQATASGALPLNSSTSLEKNNVLFGERYLEKFYGLEINKLPVTKMKYSGNLM
KEKIQEMQHFLGLKVTGQLDTSTLEMMHAPRCGVPDVHHFREMPGGPVWRKHYITYRINN
YTPDMNREDVDYAIRKAFQVWSNVTPLKFSKINTGMADILVVFARGAHGDFHAFDGKGGI
LAHAFGPGSGIGGDAHFDEDEFWTTHSGGTNLFLTAVHEIGHSLGLGHSSDPKAVMFPTY
KYVDINTFRLSADDIRGIQSLYGDPKENQRLPNPDNSEPALCDPNLSFDAVTTVGNKIFF
FKDRFFWLKVSERPKTSVNLISSLWPTLPSGIEAAYEIEARNQVFLFKDDKYWLISNLRP
EPNYPKSIHSFGFPNFVKKIDAAVFNPRFYRTYFFVDNQYWRYDERRQMMDPGYPKLITK
NFQGIGPKIDAVFYSKNKYYYFFQGSNQFEYDFLLQRITKTLKSNSWFGC
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| BDBM50152637 |
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| n/a |
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| Name | BDBM50152637 |
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| Synonyms: | (4S,5S)-2-p-Tolyl-5-vinyl-4,5-dihydro-oxazole-4-thiol | CHEMBL362099 |
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| Type | Small organic molecule |
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| Emp. Form. | C12H13NOS |
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| Mol. Mass. | 219.303 |
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| SMILES | Cc1ccc(cc1)C1=N[C@@H](S)[C@@H](O1)C=C |t:8| |
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| Structure | 
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