| Reaction Details |
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 | Report a problem with these data |
| Target | Cathepsin S |
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| Ligand | BDBM50152983 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_305367 (CHEMBL832883) |
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| IC50 | 14000±n/a nM |
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| Citation |  Thurmond, RL; Beavers, MP; Cai, H; Meduna, SP; Gustin, DJ; Sun, S; Almond, HJ; Karlsson, L; Edwards, JP Nonpeptidic, noncovalent inhibitors of the cysteine protease cathepsin S. J Med Chem47:4799-801 (2004) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cathepsin S |
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| Name: | Cathepsin S |
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| Synonyms: | CATS_HUMAN | CTSS | Cathepsin S (Cat S) | cathepsin S preproprotein |
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| Type: | Protein |
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| Mol. Mass.: | 37507.38 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P25774 |
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| Residue: | 331 |
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| Sequence: | MKRLVCVLLVCSSAVAQLHKDPTLDHHWHLWKKTYGKQYKEKNEEAVRRLIWEKNLKFVM
LHNLEHSMGMHSYDLGMNHLGDMTSEEVMSLMSSLRVPSQWQRNITYKSNPNRILPDSVD
WREKGCVTEVKYQGSCGACWAFSAVGALEAQLKLKTGKLVSLSAQNLVDCSTEKYGNKGC
NGGFMTTAFQYIIDNKGIDSDASYPYKAMDQKCQYDSKYRAATCSKYTELPYGREDVLKE
AVANKGPVSVGVDARHPSFFLYRSGVYYEPSCTQNVNHGVLVVGYGDLNGKEYWLVKNSW
GHNFGEEGYIRMARNKGNHCGIASFPSYPEI
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| BDBM50152983 |
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| n/a |
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| Name | BDBM50152983 |
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| Synonyms: | 1-[2-Hydroxy-3-(4-o-tolyl-piperazin-1-yl)-propyl]-3-(4-iodo-phenyl)-1,4,6,7-tetrahydro-pyrazolo[4,3-c]pyridine-5-carboxylic acid amide | CHEMBL363536 |
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| Type | Small organic molecule |
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| Emp. Form. | C27H33IN6O2 |
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| Mol. Mass. | 600.4944 |
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| SMILES | Cc1ccccc1N1CCN(CC(O)Cn2nc(c3CN(CCc23)C(N)=O)-c2ccc(I)cc2)CC1 |
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| Structure | 
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