| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Cathepsin S |
|---|
| Ligand | BDBM50152987 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_305367 (CHEMBL832883) |
|---|
| IC50 | 9500±n/a nM |
|---|
| Citation |  Thurmond, RL; Beavers, MP; Cai, H; Meduna, SP; Gustin, DJ; Sun, S; Almond, HJ; Karlsson, L; Edwards, JP Nonpeptidic, noncovalent inhibitors of the cysteine protease cathepsin S. J Med Chem47:4799-801 (2004) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Cathepsin S |
|---|
| Name: | Cathepsin S |
|---|
| Synonyms: | CATS_HUMAN | CTSS | Cathepsin S (Cat S) | cathepsin S preproprotein |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 37507.38 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P25774 |
|---|
| Residue: | 331 |
|---|
| Sequence: | MKRLVCVLLVCSSAVAQLHKDPTLDHHWHLWKKTYGKQYKEKNEEAVRRLIWEKNLKFVM
LHNLEHSMGMHSYDLGMNHLGDMTSEEVMSLMSSLRVPSQWQRNITYKSNPNRILPDSVD
WREKGCVTEVKYQGSCGACWAFSAVGALEAQLKLKTGKLVSLSAQNLVDCSTEKYGNKGC
NGGFMTTAFQYIIDNKGIDSDASYPYKAMDQKCQYDSKYRAATCSKYTELPYGREDVLKE
AVANKGPVSVGVDARHPSFFLYRSGVYYEPSCTQNVNHGVLVVGYGDLNGKEYWLVKNSW
GHNFGEEGYIRMARNKGNHCGIASFPSYPEI
|
|
|
|---|
| BDBM50152987 |
|---|
| n/a |
|---|
| Name | BDBM50152987 |
|---|
| Synonyms: | 1-(3-(4-Chloro-phenyl)-1-{4-[4-(2-methoxy-phenyl)-piperazin-1-yl]-butyl}-1,4,6,7-tetrahydro-pyrazolo[4,3-c]pyridin-5-yl)-ethanone | CHEMBL189142 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C29H36ClN5O2 |
|---|
| Mol. Mass. | 522.081 |
|---|
| SMILES | COc1ccccc1N1CCN(CCCCn2nc(c3CN(CCc23)C(C)=O)-c2ccc(Cl)cc2)CC1 |
|---|
| Structure | 
|
|---|
Search and Browse
