Ki Summary

Reaction Details

Report a problem with these data

Target

Mu-type opioid receptor

Ligand

BDBM50153612

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_303543 (CHEMBL839748)

>10000±n/a nM

Citation

Chen, Z; Davies, E; Miller, WS; Shan, S; Valenzano, KJ; Kyle, DJ Design and synthesis of 4-phenyl piperidine compounds targeting the mu receptor. Bioorg Med Chem Lett14:5275-9 (2004) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Mu-type opioid receptor

Name:

Mu-type opioid receptor

Synonyms:

Type:

G Protein-Coupled Receptor (GPCR)

Mol. Mass.:

44789.51

Organism:

Homo sapiens (Human)

Description:

P35372

Residue:

400

Sequence:

MDSSAAPTNASNCTDALAYSSCSPAPSPGSWVNLSHLDGNLSDPCGPNRTDLGGRDSLCP
PTGSPSMITAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALAT
STLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDF
RTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFI
FAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHI
YVIIKALVTIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSNI
EQQNSTRIRQNTRDHPSTANTVDRTNHQLENLEAETAPLP

BDBM50153612

n/a

Name

BDBM50153612

Synonyms:

4-(4-Chloro-3-trifluoromethyl-phenyl)-1-naphthalen-2-ylmethyl-1-oxy-piperidin-4-ol | CHEMBL187083

Type

Small organic molecule

Emp. Form.

C23H21ClF3NO2

Mol. Mass.

435.867

SMILES

OC1(CC[N+]([O-])(Cc2ccc3ccccc3c2)CC1)c1ccc(Cl)c(c1)C(F)(F)F |(-1.02,2.26,;.31,1.49,;-1.02,.72,;-1.02,-.82,;.31,-1.59,;1.64,-2.36,;-.48,-2.92,;-2.02,-2.89,;-2.77,-1.55,;-4.31,-1.52,;-5.08,-2.85,;-6.62,-2.85,;-7.41,-4.18,;-6.64,-5.51,;-5.1,-5.53,;-4.33,-4.21,;-2.79,-4.21,;1.64,-.82,;1.64,.72,;1.41,2.58,;.99,4.08,;2.06,5.17,;3.58,4.8,;4.65,5.9,;3.97,3.29,;2.9,2.19,;5.49,2.91,;6.77,3.87,;6.84,2.56,;6.14,1.45,)|

Structure