Ki Summary

Reaction Details

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Target

Mu-type opioid receptor

Ligand

BDBM50153618

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_303543 (CHEMBL839748)

8128±n/a nM

Citation

Chen, Z; Davies, E; Miller, WS; Shan, S; Valenzano, KJ; Kyle, DJ Design and synthesis of 4-phenyl piperidine compounds targeting the mu receptor. Bioorg Med Chem Lett14:5275-9 (2004) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Mu-type opioid receptor

Name:

Mu-type opioid receptor

Synonyms:

Type:

G Protein-Coupled Receptor (GPCR)

Mol. Mass.:

44789.51

Organism:

Homo sapiens (Human)

Description:

P35372

Residue:

400

Sequence:

MDSSAAPTNASNCTDALAYSSCSPAPSPGSWVNLSHLDGNLSDPCGPNRTDLGGRDSLCP
PTGSPSMITAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALAT
STLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDF
RTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFI
FAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHI
YVIIKALVTIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSNI
EQQNSTRIRQNTRDHPSTANTVDRTNHQLENLEAETAPLP

BDBM50153618

n/a

Name

BDBM50153618

Synonyms:

1-(3,3-Diphenyl-propyl)-1-oxy-4-(3-trifluoromethyl-phenyl)-piperidin-4-ol | CHEMBL184496

Type

Small organic molecule

Emp. Form.

C27H28F3NO2

Mol. Mass.

455.5119

SMILES

OC1(CC[N+]([O-])(CCC(c2ccccc2)c2ccccc2)CC1)c1cccc(c1)C(F)(F)F |(-.85,3.59,;.47,2.82,;1.8,2.05,;1.8,.51,;.47,-.24,;1.8,-1.01,;-.32,-1.57,;-1.86,-1.55,;-2.63,-2.88,;-1.87,-4.22,;-2.67,-5.53,;-1.93,-6.88,;-.37,-6.9,;.4,-5.56,;-.34,-4.22,;-4.17,-2.85,;-4.93,-1.52,;-6.45,-1.49,;-7.24,-2.82,;-6.5,-4.17,;-4.96,-4.17,;-.85,.51,;-.85,2.05,;1.57,3.92,;1.15,5.41,;2.24,6.5,;3.74,6.15,;4.13,4.63,;3.06,3.54,;5.65,4.24,;6.93,5.2,;7,3.89,;6.3,2.79,)|

Structure