| Reaction Details |
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 | Report a problem with these data |
| Target | Serine/threonine-protein kinase 16 |
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| Ligand | BDBM50585191 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2161722 (CHEMBL5046583) |
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| IC50 | 82±n/a nM |
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| Citation |  Drewry, DH; Annor-Gyamfi, JK; Wells, CI; Pickett, JE; Dederer, V; Preuss, F; Mathea, S; Axtman, AD Identification of Pyrimidine-Based Lead Compounds for Understudied Kinases Implicated in Driving Neurodegeneration. J Med Chem65:1313-1328 (2022) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Serine/threonine-protein kinase 16 |
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| Name: | Serine/threonine-protein kinase 16 |
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| Synonyms: | MPSK1 | PKL12 | STK16 | STK16_HUMAN | Serine/threonine-protein kinase 16 | TSF1 | Tyrosine-protein kinase STK16 (STK16) |
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| Type: | Protein |
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| Mol. Mass.: | 34659.07 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 305 |
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| Sequence: | MGHALCVCSRGTVIIDNKRYLFIQKLGEGGFSYVDLVEGLHDGHFYALKRILCHEQQDRE
EAQREADMHRLFNHPNILRLVAYCLRERGAKHEAWLLLPFFKRGTLWNEIERLKDKGNFL
TEDQILWLLLGICRGLEAIHAKGYAHRDLKPTNILLGDEGQPVLMDLGSMNQACIHVEGS
RQALTLQDWAAQRCTISYRAPELFSVQSHCVIDERTDVWSLGCVLYAMMFGEGPYDMVFQ
KGDSVALAVQNQLSIPQSPRHSSALRQLLNSMMTVDPHQRPHIPLLLSQLEALQPPAPGQ
HTTQI
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| BDBM50585191 |
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| n/a |
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| Name | BDBM50585191 |
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| Synonyms: | CHEMBL5079149 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H24BrN7O3S |
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| Mol. Mass. | 546.44 |
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| SMILES | NS(=O)(=O)c1ccc(CNc2nc(Nc3cccc(NC(=O)N4CCCC4)c3)ncc2Br)cc1 |
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| Structure | 
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