| Reaction Details |
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 | Report a problem with these data |
| Target | Sphingosine 1-phosphate receptor 2 |
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| Ligand | BDBM50585272 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2161852 (CHEMBL5046713) |
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| IC50 | 4.8±n/a nM |
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| Citation |  Mammoliti, O; Jansen, K; El Bkassiny, S; Palisse, A; Triballeau, N; Bucher, D; Allart, B; Jaunet, A; Tricarico, G; De Wachter, M; Menet, C; Blanc, J; Letfus, V; Rup?i?, R; ?mehil, M; Poljak, T; Coornaert, B; Sonck, K; Duys, I; Waeckel, L; Lecru, L; Marsais, F; Jagerschmidt, C; Auberval, M; Pujuguet, P; Oste, L; Borgonovi, M; Wakselman, E; Christophe, T; Houvenaghel, N; Jans, M; Heckmann, B; Sanière, L; Brys, R Discovery and Optimization of Orally Bioavailable Phthalazone and Cinnolone Carboxylic Acid Derivatives as S1P2 Antagonists against Fibrotic Diseases. J Med Chem64:14557-14586 (2021) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Sphingosine 1-phosphate receptor 2 |
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| Name: | Sphingosine 1-phosphate receptor 2 |
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| Synonyms: | EDG5 | S1P2 | S1PR2 | S1PR2_HUMAN | Sphingosine 1-phosphate receptor | Sphingosine 1-phosphate receptor Edg-5 | Sphingosine-1-phosphate receptor 2 | ndothelial differentiation G-protein coupled receptor 5 |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 38883.16 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Membranes isolated from S1P2-transfected CHO cells were used in ligand binding assay. |
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| Residue: | 353 |
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| Sequence: | MGSLYSEYLNPNKVQEHYNYTKETLETQETTSRQVASAFIVILCCAIVVENLLVLIAVAR
NSKFHSAMYLFLGNLAASDLLAGVAFVANTLLSGSVTLRLTPVQWFAREGSAFITLSASV
FSLLAIAIERHVAIAKVKLYGSDKSCRMLLLIGASWLISLVLGGLPILGWNCLGHLEACS
TVLPLYAKHYVLCVVTIFSIILLAIVALYVRIYCVVRSSHADMAAPQTLALLKTVTIVLG
VFIVCWLPAFSILLLDYACPVHSCPILYKAHYFFAVSTLNSLLNPVIYTWRSRDLRREVL
RPLQCWRPGVGVQGRRRGGTPGHHLLPLRSSSSLERGMHMPTSPTFLEGNTVV
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| BDBM50585272 |
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| n/a |
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| Name | BDBM50585272 |
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| Synonyms: | CHEMBL5078844 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H19ClN4O4 |
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| Mol. Mass. | 438.864 |
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| SMILES | OC(=O)Cc1nn(Cc2cn3cc(OCC4CC4)c(Cl)cc3n2)c2ccccc2c1=O |
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| Structure | 
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