| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Ceramide glucosyltransferase |
|---|
| Ligand | BDBM50585883 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_2164214 (CHEMBL5049075) |
|---|
| IC50 | >100000±n/a nM |
|---|
| Citation |  Tanaka, Y; Seto, M; Kakegawa, K; Takami, K; Kikuchi, F; Yamamoto, T; Nakamura, M; Daini, M; Murakami, M; Ohashi, T; Kasahara, T; Wang, J; Ikeda, Z; Wada, Y; Puenner, F; Fujii, T; Inazuka, M; Sato, S; Suzaki, T; Oak, JH; Takai, Y; Kohara, H; Kimoto, K; Oki, H; Mikami, S; Sasaki, M; Tanaka, Y Discovery of Brain-Penetrant Glucosylceramide Synthase Inhibitors with a Novel Pharmacophore. J Med Chem65:4270-4290 (2022) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Ceramide glucosyltransferase |
|---|
| Name: | Ceramide glucosyltransferase |
|---|
| Synonyms: | CEGT_HUMAN | GCS | GLCT-1 | Glucosylceramide synthase | UDP-glucose ceramide glucosyltransferase | UDP-glucose:N-acylsphingosine D-glucosyltransferase | UGCG |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 44859.25 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_1435474 |
|---|
| Residue: | 394 |
|---|
| Sequence: | MALLDLALEGMAVFGFVLFLVLWLMHFMAIIYTRLHLNKKATDKQPYSKLPGVSLLKPLK
GVDPNLINNLETFFELDYPKYEVLLCVQDHDDPAIDVCKKLLGKYPNVDARLFIGGKKVG
INPKINNLMPGYEVAKYDLIWICDSGIRVIPDTLTDMVNQMTEKVGLVHGLPYVADRQGF
AATLEQVYFGTSHPRYYISANVTGFKCVTGMSCLMRKDVLDQAGGLIAFAQYIAEDYFMA
KAIADRGWRFAMSTQVAMQNSGSYSISQFQSRMIRWTKLRINMLPATIICEPISECFVAS
LIIGWAAHHVFRWDIMVFFMCHCLAWFIFDYIQLRGVQGGTLCFSKLDYAVAWFIRESMT
IYIFLSALWDPTISWRTGRYRLRCGGTAEEILDV
|
|
|
|---|
| BDBM50585883 |
|---|
| n/a |
|---|
| Name | BDBM50585883 |
|---|
| Synonyms: | CHEMBL5085627 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C20H22N2O2 |
|---|
| Mol. Mass. | 322.4009 |
|---|
| SMILES | COc1ccccc1-c1nccc2C(=O)N(Cc12)C1CCCCC1 |
|---|
| Structure | 
|
|---|
Search and Browse
