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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Histone-lysine N-methyltransferase EZH2 | ||
| Ligand | BDBM50586155 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_2165239 (CHEMBL5050100) | ||
| IC50 | 302±n/a nM | ||
| Citation |  Liang, R; Tomita, D; Sasaki, Y; Ginn, J; Michino, M; Huggins, DJ; Baxt, L; Kargman, S; Shahid, M; Aso, K; Duggan, M; Stamford, AW; DeStanchina, E; Liverton, N; Meinke, PT; Foley, MA; Phillips, RE A Chemical Strategy toward Novel Brain-Penetrant EZH2 Inhibitors. ACS Med Chem Lett13:377-387 (2022) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Histone-lysine N-methyltransferase EZH2 | |||
| Name: | Histone-lysine N-methyltransferase EZH2 | ||
| Synonyms: | ENX-1 | EZH2 | EZH2_HUMAN | Enhancer of zeste homolog 2 (EZH2) | Histone-lysine N-methyltransferase EZH2 | KMT6 | Lysine N-methyltransferase 6 | ||
| Type: | Protein | ||
| Mol. Mass.: | 85367.84 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Q15910 | ||
| Residue: | 746 | ||
| Sequence: |
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| BDBM50586155 | |||
| n/a | |||
| Name | BDBM50586155 | ||
| Synonyms: | CHEMBL5081796 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C25H25Cl2N3O3 | ||
| Mol. Mass. | 486.39 | ||
| SMILES | Cc1noc(C)c1-c1cc(Cl)c2CCN(Cc3c(cc(C)n(C)c3=O)C3CC3)C(=O)c2c1Cl |(-7.25,-1.11,;-6.85,.37,;-7.88,1.52,;-7.11,2.85,;-5.61,2.53,;-4.52,3.62,;-5.45,1,;-4.11,.23,;-4.11,-1.32,;-2.78,-2.08,;-2.78,-3.62,;-1.45,-1.31,;-.12,-2.08,;1.22,-1.31,;1.22,.23,;2.55,1,;3.88,.23,;3.88,-1.31,;5.22,-2.08,;6.55,-1.31,;7.88,-2.08,;6.55,.23,;7.88,1,;5.22,1,;5.22,2.54,;2.55,-2.08,;1.01,-2.08,;1.78,-3.41,;-.12,1,;-.12,2.54,;-1.45,.23,;-2.78,1,;-2.78,2.54,)| | ||
| Structure | 
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