| Reaction Details |
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 | Report a problem with these data |
| Target | Nuclear receptor ROR-gamma |
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| Ligand | BDBM50586397 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2168563 (CHEMBL5053622) |
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| Ki | 139±n/a nM |
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| Citation |  Lugar, CW; Clarke, CA; Morphy, R; Rudyk, H; Sapmaz, S; Stites, RE; Vaught, GM; Furness, K; Broughton, HB; Durst, GL; Clawson, DK; Stout, SL; Guo, SY; Durbin, JD; Stayrook, KR; Edmondson, DD; Kikly, K; New, NE; Bina, HA; Chambers, MG; Shetler, P; Chang, WY; Chang, VC; Barr, R; Gough, WH; Steele, JP; Getman, B; Patel, N; Mathes, BM; Richardson, TI Defining Target Engagement Required for Efficacy J Med Chem64:5470-5484 (2021) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Nuclear receptor ROR-gamma |
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| Name: | Nuclear receptor ROR-gamma |
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| Synonyms: | NR1F3 | Nuclear receptor ROR-gamma | Nuclear receptor ROR-gamma (RORC) | Nuclear receptor subfamily 1 group F member 3 | RAR-related orphan receptor C (RORc) | RORC | RORG | RORG_HUMAN | RZRG | Retinoid-related orphan receptor-gamma | Retinoid-related orphan receptor-gamma (RORc) |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 58218.40 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P51449 |
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| Residue: | 518 |
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| Sequence: | MDRAPQRQHRASRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQR
CNAAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQK
QLQQRQQQQQEPVVKTPPAGAQGADTLTYTLGLPDGQLPLGSSPDLPEASACPPGLLKAS
GSGPSYSNNLAKAGLNGASCHLEYSPERGKAEGRESFYSTGSQLTPDRCGLRFEEHRHPG
LGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIF
SREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEV
VLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALY
TALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHV
ERLQIFQHLHPIVVQAAFPPLYKELFSTETESPVGLSK
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| BDBM50586397 |
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| n/a |
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| Name | BDBM50586397 |
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| Synonyms: | CHEMBL5092218 |
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| Type | Small organic molecule |
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| Emp. Form. | C29H32N4O4S2 |
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| Mol. Mass. | 564.719 |
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| SMILES | CCS(=O)(=O)c1ccc(CNC(=O)c2cc3CCOC4(CCN(CC4)[C@H](C)c4ccc(cc4)C#N)c3s2)nc1 |r| |
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| Structure | 
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