| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Epithelial discoidin domain-containing receptor 1 |
|---|
| Ligand | BDBM50586583 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_2169097 (CHEMBL5054156) |
|---|
| IC50 | 16500±n/a nM |
|---|
| Citation |  Röhm, S; Berger, BT; Schröder, M; Chatterjee, D; Mathea, S; Joerger, AC; Pinkas, DM; Bufton, JC; Tjaden, A; Kovooru, L; Kudolo, M; Pohl, C; Bullock, AN; Müller, S; Laufer, S; Knapp, S Development of a Selective Dual Discoidin Domain Receptor (DDR)/p38 Kinase Chemical Probe. J Med Chem64:13451-13474 (2021) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Epithelial discoidin domain-containing receptor 1 |
|---|
| Name: | Epithelial discoidin domain-containing receptor 1 |
|---|
| Synonyms: | CAK | DDR1 | DDR1_HUMAN | Discoidin domain receptor 1 (DDR1) | Discoidin domain-containing receptor 1 (DDR1) | Discoidin receptor tyrosine kinase | EDDR1 | Epithelial discoidin domain receptor 1 | Epithelial discoidin domain receptor 1 (DDR1) | Epithelial discoidin domain-containing receptor 1 | Epithelial discoidin domain-containing receptor 1 (DDR1) | HGK2 | Mammary carcinoma kinase 10 | NEP | NTRK4 | PTK3A | Protein-tyrosine kinase RTK 6 | RTK6 | TRKE | Tyrosine-protein kinase CAK |
|---|
| Type: | Tyrosine-protein kinase |
|---|
| Mol. Mass.: | 101130.02 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q08345 |
|---|
| Residue: | 913 |
|---|
| Sequence: | MGPEALSSLLLLLLVASGDADMKGHFDPAKCRYALGMQDRTIPDSDISASSSWSDSTAAR
HSRLESSDGDGAWCPAGSVFPKEEEYLQVDLQRLHLVALVGTQGRHAGGLGKEFSRSYRL
RYSRDGRRWMGWKDRWGQEVISGNEDPEGVVLKDLGPPMVARLVRFYPRADRVMSVCLRV
ELYGCLWRDGLLSYTAPVGQTMYLSEAVYLNDSTYDGHTVGGLQYGGLGQLADGVVGLDD
FRKSQELRVWPGYDYVGWSNHSFSSGYVEMEFEFDRLRAFQAMQVHCNNMHTLGARLPGG
VECRFRRGPAMAWEGEPMRHNLGGNLGDPRARAVSVPLGGRVARFLQCRFLFAGPWLLFS
EISFISDVVNNSSPALGGTFPPAPWWPPGPPPTNFSSLELEPRGQQPVAKAEGSPTAILI
GCLVAIILLLLLIIALMLWRLHWRRLLSKAERRVLEEELTVHLSVPGDTILINNRPGPRE
PPPYQEPRPRGNPPHSAPCVPNGSALLLSNPAYRLLLATYARPPRGPGPPTPAWAKPTNT
QAYSGDYMEPEKPGAPLLPPPPQNSVPHYAEADIVTLQGVTGGNTYAVPALPPGAVGDGP
PRVDFPRSRLRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKILRPD
ATKNARNDFLKEVKIMSRLKDPNIIRLLGVCVQDDPLCMITDYMENGDLNQFLSAHQLED
KAAEGAPGDGQAAQGPTISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVGENFTI
KIADFGMSRNLYAGDYYRVQGRAVLPIRWMAWECILMGKFTTASDVWAFGVTLWEVLMLC
RAQPFGQLTDEQVIENAGEFFRDQGRQVYLSRPPACPQGLYELMLRCWSRESEQRPPFSQ
LHRFLAEDALNTV
|
|
|
|---|
| BDBM50586583 |
|---|
| n/a |
|---|
| Name | BDBM50586583 |
|---|
| Synonyms: | CHEMBL5092902 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C35H46N6O5S |
|---|
| Mol. Mass. | 662.842 |
|---|
| SMILES | CC(NC(=O)c1cc(n[nH]1)-c1ccccc1)c1ccc(cc1)C(=O)N[C@@H](CCC1CCCCC1)C(=O)NC1CCCN(C1)S(C)(=O)=O |r| |
|---|
| Structure | 
|
|---|
Search and Browse
