| Reaction Details |
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 | Report a problem with these data |
| Target | Discoidin domain-containing receptor 2 |
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| Ligand | BDBM50586581 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2169100 (CHEMBL5054159) |
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| IC50 | 3720±n/a nM |
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| Citation |  Röhm, S; Berger, BT; Schröder, M; Chatterjee, D; Mathea, S; Joerger, AC; Pinkas, DM; Bufton, JC; Tjaden, A; Kovooru, L; Kudolo, M; Pohl, C; Bullock, AN; Müller, S; Laufer, S; Knapp, S Development of a Selective Dual Discoidin Domain Receptor (DDR)/p38 Kinase Chemical Probe. J Med Chem64:13451-13474 (2021) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Discoidin domain-containing receptor 2 |
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| Name: | Discoidin domain-containing receptor 2 |
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| Synonyms: | DDR2 | DDR2_HUMAN | Discoidin domain receptor 2 (DDR2) | Discoidin domain-containing receptor 2 | Discoidin domain-containing receptor 2 (DDR2) | Epithelial discoidin domain-containing receptor 2 (DDR2) | NTRKR3 | TKT | TYRO10 |
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| Type: | Protein |
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| Mol. Mass.: | 96717.07 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q16832 |
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| Residue: | 855 |
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| Sequence: | MILIPRMLLVLFLLLPILSSAKAQVNPAICRYPLGMSGGQIPDEDITASSQWSESTAAKY
GRLDSEEGDGAWCPEIPVEPDDLKEFLQIDLHTLHFITLVGTQGRHAGGHGIEFAPMYKI
NYSRDGTRWISWRNRHGKQVLDGNSNPYDIFLKDLEPPIVARFVRFIPVTDHSMNVCMRV
ELYGCVWLDGLVSYNAPAGQQFVLPGGSIIYLNDSVYDGAVGYSMTEGLGQLTDGVSGLD
DFTQTHEYHVWPGYDYVGWRNESATNGYIEIMFEFDRIRNFTTMKVHCNNMFAKGVKIFK
EVQCYFRSEASEWEPNAISFPLVLDDVNPSARFVTVPLHHRMASAIKCQYHFADTWMMFS
EITFQSDAAMYNNSEALPTSPMAPTTYDPMLKVDDSNTRILIGCLVAIIFILLAIIVIIL
WRQFWQKMLEKASRRMLDDEMTVSLSLPSDSSMFNNNRSSSPSEQGSNSTYDRIFPLRPD
YQEPSRLIRKLPEFAPGEEESGCSGVVKPVQPSGPEGVPHYAEADIVNLQGVTGGNTYSV
PAVTMDLLSGKDVAVEEFPRKLLTFKEKLGEGQFGEVHLCEVEGMEKFKDKDFALDVSAN
QPVLVAVKMLRADANKNARNDFLKEIKIMSRLKDPNIIHLLAVCITDDPLCMITEYMENG
DLNQFLSRHEPPNSSSSDVRTVSYTNLKFMATQIASGMKYLSSLNFVHRDLATRNCLVGK
NYTIKIADFGMSRNLYSGDYYRIQGRAVLPIRWMSWESILLGKFTTASDVWAFGVTLWET
FTFCQEQPYSQLSDEQVIENTGEFFRDQGRQTYLPQPAICPDSVYKLMLSCWRRDTKNRP
SFQEIHLLLLQQGDE
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| BDBM50586581 |
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| n/a |
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| Name | BDBM50586581 |
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| Synonyms: | CHEMBL5079394 |
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| Type | Small organic molecule |
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| Emp. Form. | C36H47N7O4 |
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| Mol. Mass. | 641.8029 |
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| SMILES | Nc1c(cnn1-c1ccccc1)C(=O)NCc1ccc(cc1)C(=O)N[C@@H](CCC1CCCCC1)C(=O)NC1CCCN(C1)C1COC1 |r| |
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| Structure | 
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