| Reaction Details |
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 | Report a problem with these data |
| Target | Bifunctional epoxide hydrolase 2 |
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| Ligand | BDBM50586929 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2170254 (CHEMBL5055313) |
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| IC50 | 87±n/a nM |
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| Citation |  Lillich, FF; Willems, S; Ni, X; Kilu, W; Borkowsky, C; Brodsky, M; Kramer, JS; Brunst, S; Hernandez-Olmos, V; Heering, J; Schierle, S; Kestner, RI; Mayser, FM; Helmstädter, M; Göbel, T; Weizel, L; Namgaladze, D; Kaiser, A; Steinhilber, D; Pfeilschifter, W; Kahnt, AS; Proschak, A; Chaikuad, A; Knapp, S; Merk, D; Proschak, E Structure-Based Design of Dual Partial Peroxisome Proliferator-Activated Receptor ? Agonists/Soluble Epoxide Hydrolase Inhibitors. J Med Chem64:17259-17276 (2021) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Bifunctional epoxide hydrolase 2 |
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| Name: | Bifunctional epoxide hydrolase 2 |
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| Synonyms: | Cytosolic epoxide hydrolase 2 | EBifunctional epoxide hydrolase 2 | EPHX2 | Epoxide hydratase | HYES_HUMAN | Lipid-phosphate phosphatase | Soluble epoxide hydrolase (sEH) | epoxide hydrolase 2, cytoplasmic |
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| Type: | Enzyme |
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| Mol. Mass.: | 62613.07 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P34913 |
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| Residue: | 555 |
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| Sequence: | MTLRAAVFDLDGVLALPAVFGVLGRTEEALALPRGLLNDAFQKGGPEGATTRLMKGEITL
SQWIPLMEENCRKCSETAKVCLPKNFSIKEIFDKAISARKINRPMLQAALMLRKKGFTTA
ILTNTWLDDRAERDGLAQLMCELKMHFDFLIESCQVGMVKPEPQIYKFLLDTLKASPSEV
VFLDDIGANLKPARDLGMVTILVQDTDTALKELEKVTGIQLLNTPAPLPTSCNPSDMSHG
YVTVKPRVRLHFVELGSGPAVCLCHGFPESWYSWRYQIPALAQAGYRVLAMDMKGYGESS
APPEIEEYCMEVLCKEMVTFLDKLGLSQAVFIGHDWGGMLVWYMALFYPERVRAVASLNT
PFIPANPNMSPLESIKANPVFDYQLYFQEPGVAEAELEQNLSRTFKSLFRASDESVLSMH
KVCEAGGLFVNSPEEPSLSRMVTEEEIQFYVQQFKKSGFRGPLNWYRNMERNWKWACKSL
GRKILIPALMVTAEKDFVLVPQMSQHMEDWIPHLKRGHIEDCGHWTQMDKPTEVNQILIK
WLDSDARNPPVVSKM
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| BDBM50586929 |
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| n/a |
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| Name | BDBM50586929 |
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| Synonyms: | CHEMBL5083326 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H17ClF3N3O2 |
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| Mol. Mass. | 459.848 |
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| SMILES | FC(F)(F)c1ccccc1CNC(=O)c1ccc2n(Cc3cccc(Cl)c3)c(=O)[nH]c2c1 |
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| Structure | 
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