| Reaction Details |
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 | Report a problem with these data |
| Target | Histone deacetylase 8 |
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| Ligand | BDBM50587184 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2171609 (CHEMBL5056743) |
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| IC50 | >200±n/a nM |
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| Citation |  Wang, J; Cao, Z; Wang, F; Wang, P; An, J; Fu, X; Liu, T; Li, Y; Li, Y; Zhao, Y; Lin, H; He, B Cysteine derivatives as acetyl lysine mimics to inhibit zinc-dependent histone deacetylases for treating cancer. Eur J Med Chem225:0 (2021) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Histone deacetylase 8 |
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| Name: | Histone deacetylase 8 |
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| Synonyms: | HD8 | HDAC8 | HDAC8_HUMAN | HDACL1 | Histone deacetylase 8 (HDAC-8) | Human HDAC8 |
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| Type: | Enzyme |
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| Mol. Mass.: | 41749.60 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9BY41 |
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| Residue: | 377 |
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| Sequence: | MEEPEEPADSGQSLVPVYIYSPEYVSMCDSLAKIPKRASMVHSLIEAYALHKQMRIVKPK
VASMEEMATFHTDAYLQHLQKVSQEGDDDHPDSIEYGLGYDCPATEGIFDYAAAIGGATI
TAAQCLIDGMCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFERILYVDLDLH
HGDGVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSVNVPIQDGIQDEKY
YQICESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLI
LGGGGYNLANTARCWTYLTGVILGKTLSSEIPDHEFFTAYGPDYVLEITPSCRPDRNEPH
RIQQILNYIKGNLKHVV
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| BDBM50587184 |
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| n/a |
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| Name | BDBM50587184 |
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| Synonyms: | CHEMBL5089854 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H23N3O4S |
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| Mol. Mass. | 401.479 |
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| SMILES | ONC(=O)CCCSC[C@H](NC(=O)c1ccccc1)C(=O)Nc1ccccc1 |r| |
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| Structure | 
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