| Reaction Details |
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 | Report a problem with these data |
| Target | B-cell lymphoma 6 protein |
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| Ligand | BDBM522280 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2172844 (CHEMBL5057978) |
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| IC50 | <3.0±n/a nM |
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| Citation |  Lloyd, MG; Huckvale, R; Cheung, KJ; Rodrigues, MJ; Collie, GW; Pierrat, OA; Gatti Iou, M; Carter, M; Davis, OA; McAndrew, PC; Gunnell, E; Le Bihan, YV; Talbot, R; Henley, AT; Johnson, LD; Hayes, A; Bright, MD; Raynaud, FI; Meniconi, M; Burke, R; van Montfort, RLM; Rossanese, OW; Bellenie, BR; Hoelder, S Into Deep Water: Optimizing BCL6 Inhibitors by Growing into a Solvated Pocket. J Med Chem64:17079-17097 (2021) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| B-cell lymphoma 6 protein |
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| Name: | B-cell lymphoma 6 protein |
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| Synonyms: | B-cell lymphoma 5 protein | B-cell lymphoma 6 protein | BCL-5 | BCL-6 | BCL5 | BCL6 | BCL6_HUMAN | BCoR-BCL6 | LAZ3 | Protein LAZ-3 | ZBTB27 | ZNF51 | Zinc finger and BTB domain-containing protein 27 | Zinc finger protein 51 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 78866.89 |
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| Organism: | Homo sapiens |
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| Description: | ChEMBL_117695 |
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| Residue: | 706 |
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| Sequence: | MASPADSCIQFTRHASDVLLNLNRLRSRDILTDVVIVVSREQFRAHKTVLMACSGLFYSI
FTDQLKCNLSVINLDPEINPEGFCILLDFMYTSRLNLREGNIMAVMATAMYLQMEHVVDT
CRKFIKASEAEMVSAIKPPREEFLNSRMLMPQDIMAYRGREVVENNLPLRSAPGCESRAF
APSLYSGLSTPPASYSMYSHLPVSSLLFSDEEFRDVRMPVANPFPKERALPCDSARPVPG
EYSRPTLEVSPNVCHSNIYSPKETIPEEARSDMHYSVAEGLKPAAPSARNAPYFPCDKAS
KEEERPSSEDEIALHFEPPNAPLNRKGLVSPQSPQKSDCQPNSPTESCSSKNACILQASG
SPPAKSPTDPKACNWKKYKFIVLNSLNQNAKPEGPEQAELGRLSPRAYTAPPACQPPMEP
ENLDLQSPTKLSASGEDSTIPQASRLNNIVNRSMTGSPRSSSESHSPLYMHPPKCTSCGS
QSPQHAEMCLHTAGPTFPEEMGETQSEYSDSSCENGAFFCNECDCRFSEEASLKRHTLQT
HSDKPYKCDRCQASFRYKGNLASHKTVHTGEKPYRCNICGAQFNRPANLKTHTRIHSGEK
PYKCETCGARFVQVAHLRAHVLIHTGEKPYPCEICGTRFRHLQTLKSHLRIHTGEKPYHC
EKCNLHFRHKSQLRLHLRQKHGAITNTKVQYRVSATDLPPELPKAC
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| BDBM522280 |
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| n/a |
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| Name | BDBM522280 |
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| Synonyms: | US11161839, Example 10a |
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| Type | Small organic molecule |
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| Emp. Form. | C26H24ClN7O |
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| Mol. Mass. | 485.968 |
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| SMILES | Cn1c2ccc(Nc3ccnc(Cl)c3C#N)cc2c(NC(C)(C)c2ncc(cn2)C2CC2)cc1=O |
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| Structure | 
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