| Reaction Details |
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 | Report a problem with these data |
| Target | cAMP-dependent protein kinase catalytic subunit gamma |
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| Ligand | BDBM14027 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2185221 (CHEMBL5097303) |
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| IC50 | 4580±n/a nM |
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| Citation |  Lee, S; Kim, J; Jo, J; Chang, JW; Sim, J; Yun, H Recent advances in development of hetero-bivalent kinase inhibitors. Eur J Med Chem216:0 (2021) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| cAMP-dependent protein kinase catalytic subunit gamma |
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| Name: | cAMP-dependent protein kinase catalytic subunit gamma |
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| Synonyms: | KAPCG_HUMAN | PKA C-gamma | PRKACG | cAMP-dependent protein kinase (PKA) | cAMP-dependent protein kinase catalytic subunit gamma |
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| Type: | PROTEIN |
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| Mol. Mass.: | 40442.03 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_104720 |
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| Residue: | 351 |
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| Sequence: | MGNAPAKKDTEQEESVNEFLAKARGDFLYRWGNPAQNTASSDQFERLRTLGMGSFGRVML
VRHQETGGHYAMKILNKQKVVKMKQVEHILNEKRILQAIDFPFLVKLQFSFKDNSYLYLV
MEYVPGGEMFSRLQRVGRFSEPHACFYAAQVVLAVQYLHSLDLIHRDLKPENLLIDQQGY
LQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAVGFPPFY
ADQPIQIYEKIVSGRVRFPSKLSSDLKHLLRSLLQVDLTKRFGNLRNGVGDIKNHKWFAT
TSWIAIYEKKVEAPFIPKYTGPGDASNFDDYEEEELRISINEKCAKEFSEF
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| BDBM14027 |
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| n/a |
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| Name | BDBM14027 |
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| Synonyms: | 5-(1,4-diazepan-1-ylsulfonyl)isoquinoline | 5-(1,4-diazepane-1-sulfonyl)isoquinoline | AT877 | CHEMBL38380 | CHEMBL541388 | Fasudil (HA-1077) | HA-1077 | US9687483, Fasudil | cid_163751 |
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| Type | Small organic molecule |
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| Emp. Form. | C14H17N3O2S |
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| Mol. Mass. | 291.369 |
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| SMILES | O=S(=O)(N1CCCNCC1)c1cccc2cnccc12 |
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| Structure | 
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