| Reaction Details |
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 | Report a problem with these data |
| Target | Mitogen-activated protein kinase 7 |
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| Ligand | BDBM50507989 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2185245 (CHEMBL5097327) |
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| IC50 | 120±n/a nM |
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| Citation |  Lee, S; Kim, J; Jo, J; Chang, JW; Sim, J; Yun, H Recent advances in development of hetero-bivalent kinase inhibitors. Eur J Med Chem216:0 (2021) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Mitogen-activated protein kinase 7 |
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| Name: | Mitogen-activated protein kinase 7 |
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| Synonyms: | 2.7.11.24 | BMK-1 | Big MAP kinase 1 | Bmk1 | ERK-5 | Erk5 | Extracellular signal-regulated kinase 5 | MAP kinase 7 | MAPK 7 | MK07_MOUSE | Mapk7 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 87722.05 |
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| Organism: | Mus musculus |
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| Description: | ChEMBL_120745 |
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| Residue: | 806 |
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| Sequence: | MAEPLKEEDGEDGSGEPPGRVKAEPVHTAASVVAKNLALLKARSFDVTFDVGDEYEIIET
IGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKILKHFKHDNIIAIKDI
LKPTVPYGEFRSVYVVLDLMESDLHQIIHSSQPLTLEHVRYFLYQLLRGLKYMHSAQVIH
RDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQYFMTEYVATRWYRAPELMLSLHEYT
QAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLGTPSPAVIQAVGAERVRAYIQS
LPPRQPVPWETVYPGADRQALSLLGRMLRFEPSARISAAAALRHPFLAKYHDPDDEPDCA
PPFDFAFDREALTRERIKEAIVAEIEDFHARREGIRQQIRFQPSLQPVASEPVCPDVEMP
SPWAPSGDCAMESPPPALPPCSDPAPDTVDLTLQPAPPASELAPPKREGAISDNTKAALK
AALLKSLRSRLRDGPSAPLEAPEPRKPVTAQERQREREEKRRRRQERAKEREKRRQERER
KERGAGTLGGPSTDPLAGLVLSDNDRSLLERWTRMARPPAPAPAPAPAPAPAPSSAQPTS
TPTGPVSQSTGPLQPAGSIPGPASQPVCPPPGPVPQPAGPIPAPLQTAPSTSLLASQSLV
PPSGLPGSGAPEVLPYFPSGPPPPDPGLTPQPSTSESPDVNLVTQQLSKSQVEDPLPPVF
SGTPKGSGAGYGVGFDLEEFLNQSFDMGVADGPQDGQADSASLSASLLADWLEGHGMNPA
DIESLQREIQMDSPMLLSDLPDLQEP
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| BDBM50507989 |
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| n/a |
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| Name | BDBM50507989 |
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| Synonyms: | CHEMBL4445670 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H28F3N7O2 |
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| Mol. Mass. | 515.5307 |
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| SMILES | CN1CCN(CC1)c1cnc2c(ncnc2c1)C1CCN(CC1)C(=O)c1ccc(OC(F)(F)F)cc1N |
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| Structure | 
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