Reaction Details |
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Target | Tyrosine-protein phosphatase non-receptor type 11 |
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Ligand | BDBM50588243 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_2186513 (CHEMBL5098595) |
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IC50 | 22±n/a nM |
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Citation | Czako, B; Sun, Y; McAfoos, T; Cross, JB; Leonard, PG; Burke, JP; Carroll, CL; Feng, N; Harris, AL; Jiang, Y; Kang, Z; Kovacs, JJ; Mandal, P; Meyers, BA; Mseeh, F; Parker, CA; Yu, SS; Williams, CC; Wu, Q; Di Francesco, ME; Draetta, G; Heffernan, T; Marszalek, JR; Kohl, NE; Jones, P Discovery of 6-[(3 J Med Chem64:15141-15169 (2021) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Tyrosine-protein phosphatase non-receptor type 11 |
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Name: | Tyrosine-protein phosphatase non-receptor type 11 |
Synonyms: | 3.1.3.48 | PTN11_HUMAN | PTP-1D | PTP-2C | PTP2C | PTPN11 | Protein Tyrosine Phosphatase PPN11/Shp2 | Protein tyrosine phosphatase (PTP) Shp2 | Protein-Tyrosine Phosphatase SHP-2 | Protein-tyrosine phosphatase 1D | Protein-tyrosine phosphatase 2C | SH-PTP2 | SH-PTP3 | SHP-2 | SHP2 | SHPTP2 | Src homology phosphatase 2 (SHP-2) | Tyrosine-protein phosphatase non-receptor type 11 (PTPN11) | Tyrosine-protein phosphatase non-receptor type 11 (SHP-2) | Tyrosine-protein phosphatase non-receptor type 11 (SHP2) |
Type: | Protein phosphatase |
Mol. Mass.: | 68443.59 |
Organism: | Homo sapiens (Human) |
Description: | Q06124 |
Residue: | 593 |
Sequence: | MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTG
DYYDLYGGEKFATLAELVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGK
EAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYD
VGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETT
DKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEP
VSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEV
ERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHF
RTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIR
EKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGH
EYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR
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BDBM50588243 |
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n/a |
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Name | BDBM50588243 |
Synonyms: | CHEMBL5183827 |
Type | Small organic molecule |
Emp. Form. | C21H27ClN8O |
Mol. Mass. | 442.945 |
SMILES | CCNc1nccc(-c2n[nH]c3nc(cnc23)N2CCC3(CO[C@@H](C)[C@H]3N)CC2)c1Cl |r| |
Structure |
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