| Reaction Details |
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 | Report a problem with these data |
| Target | Sequestosome-1 |
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| Ligand | BDBM50588581 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2187795 (CHEMBL5099877) |
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| Kd | 1490±n/a nM |
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| Citation |  Wang, FC; Peng, B; Ren, TT; Liu, SP; Du, JR; Chen, ZH; Zhang, TT; Gu, X; Li, M; Cao, SL; Xu, X A 1,2,3-Triazole Derivative of Quinazoline Exhibits Antitumor Activity by Tethering RNF168 to SQSTM1/P62. J Med Chem65:15028-15047 (2022) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Sequestosome-1 |
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| Name: | Sequestosome-1 |
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| Synonyms: | EBI3-associated protein of 60 kDa | EBIAP | ORCA | OSIL | Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa | SQSTM1 | SQSTM_HUMAN | Ubiquitin-binding protein p62 | p60 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 47672.06 |
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| Organism: | Homo sapiens |
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| Description: | ChEMBL_118061 |
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| Residue: | 440 |
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| Sequence: | MASLTVKAYLLGKEDAAREIRRFSFCCSPEPEAEAEAAAGPGPCERLLSRVAALFPALRP
GGFQAHYRDEDGDLVAFSSDEELTMAMSYVKDDIFRIYIKEKKECRRDHRPPCAQEAPRN
MVHPNVICDGCNGPVVGTRYKCSVCPDYDLCSVCEGKGLHRGHTKLAFPSPFGHLSEGFS
HSRWLRKVKHGHFGWPGWEMGPPGNWSPRPPRAGEARPGPTAESASGPSEDPSVNFLKNV
GESVAAALSPLGIEVDIDVEHGGKRSRLTPVSPESSSTEEKSSSQPSSCCSDPSKPGGNV
EGATQSLAEQMRKIALESEGRPEEQMESDNCSGGDDDWTHLSSKEVDPSTGELQSLQMPE
SEGPSSLDPSQEGPTGLKEAALYPHLPPEADPRLIESLSQMLSMGFSDEGGWLTRLLQTK
NYDIGAALDTIQYSKHPPPL
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| BDBM50588581 |
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| n/a |
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| Name | BDBM50588581 |
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| Synonyms: | CHEMBL5183436 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H19N7O3 |
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| Mol. Mass. | 393.3993 |
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| SMILES | COc1cc(cc(OC)c1OC)-n1cc(nn1)-c1ccc2nc(N)nc(N)c2c1 |
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| Structure | 
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