Ki Summary

Reaction Details

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Target

5-hydroxytryptamine receptor 1A

Ligand

BDBM50160608

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_303397 (CHEMBL840060)

194±n/a nM

Citation

Evrard, DA; Zhou, P; Yi, SY; Zhou, D; Smith, DL; Sullivan, KM; Hornby, GA; Schechter, LE; Andree, TH; Mewshaw, RE Studies towards the next generation of antidepressants. Part 4: derivatives of 4-(5-fluoro-1H-indol-3-yl)cyclohexylamine with affinity for the serotonin transporter and the 5-HT1A receptor. Bioorg Med Chem Lett15:911-4 (2005) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

5-hydroxytryptamine receptor 1A

Name:

5-hydroxytryptamine receptor 1A

Synonyms:

Type:

n/a

Mol. Mass.:

46122.49

Organism:

Homo sapiens (Human)

Description:

n/a

Residue:

422

Sequence:

MDVLSPGQGNNTTSPPAPFETGGNTTGISDVTVSYQVITSLLLGTLIFCAVLGNACVVAA
IALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCC
TSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPED
RSDPDACTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVKKVEKTGADT
RHGASPAPQPKKSVNGESGSRNWRLGVESKAGGALCANGAVRQGDDGAALEVIEVHRVGN
SKEHLPLPSEAGPTPCAPASFERKNERNAEAKRKMALARERKTVKTLGIIMGTFILCWLP
FFIVALVLPFCESSCHMPTLLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKFC
RQ

BDBM50160608

n/a

Name

BDBM50160608

Synonyms:

(2,3-Dihydro-benzo[1,4]dioxin-2-ylmethyl)-[4-(5-fluoro-1H-indol-3-yl)-cyclohexyl]-amine | CHEMBL362430

Type

Small organic molecule

Emp. Form.

C23H25FN2O2

Mol. Mass.

380.4552

SMILES

Fc1ccc2[nH]cc([C@H]3CC[C@@H](CC3)NCC3COc4ccccc4O3)c2c1 |wU:11.14,wD:8.7,(5.88,4.43,;6.21,2.92,;7.68,2.47,;8,.97,;6.87,-.05,;6.88,-1.62,;5.42,-2.08,;4.51,-.86,;2.99,-.87,;2.2,.48,;.65,.46,;-.12,-.87,;.68,-2.22,;2.22,-2.2,;-1.63,-.89,;-2.42,.44,;-3.96,.44,;-4.75,1.77,;-6.32,1.75,;-7.06,.4,;-8.61,.37,;-9.37,-.96,;-8.58,-2.29,;-7.02,-2.27,;-6.28,-.94,;-4.74,-.92,;5.41,.41,;5.09,1.89,)|

Structure