Reaction Details | |||
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Target | 5-hydroxytryptamine receptor 1A | ||
Ligand | BDBM50160611 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_303397 (CHEMBL840060) | ||
Ki | 1.08±n/a nM | ||
Citation | Evrard, DA; Zhou, P; Yi, SY; Zhou, D; Smith, DL; Sullivan, KM; Hornby, GA; Schechter, LE; Andree, TH; Mewshaw, RE Studies towards the next generation of antidepressants. Part 4: derivatives of 4-(5-fluoro-1H-indol-3-yl)cyclohexylamine with affinity for the serotonin transporter and the 5-HT1A receptor. Bioorg Med Chem Lett15:911-4 (2005) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
5-hydroxytryptamine receptor 1A | |||
Name: | 5-hydroxytryptamine receptor 1A | ||
Synonyms: | 5-HT-1A | 5-HT1A | 5-hydroxytryptamine receptor 1A (5-HT-1A) | 5HT1A_HUMAN | ADRB2RL1 | ADRBRL1 | Dopamine D2 receptor and serotonin 1a receptor | G-21 | HTR1A | Serotonin receptor 1A | ||
Type: | n/a | ||
Mol. Mass.: | 46122.49 | ||
Organism: | Homo sapiens (Human) | ||
Description: | n/a | ||
Residue: | 422 | ||
Sequence: |
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BDBM50160611 | |||
n/a | |||
Name | BDBM50160611 | ||
Synonyms: | CHEMBL359549 | [4-(5-Fluoro-1H-indol-3-yl)-cyclohexyl]-[2-(1H-indol-4-yloxy)-ethyl]-amine | ||
Type | Small organic molecule | ||
Emp. Form. | C24H26FN3O | ||
Mol. Mass. | 391.4811 | ||
SMILES | Fc1ccc2[nH]cc([C@H]3CC[C@@H](CC3)NCCOc3cccc4[nH]ccc34)c2c1 |wU:11.14,wD:8.7,(7.29,-3.35,;7.29,-1.79,;8.62,-1.03,;8.62,.53,;7.29,1.29,;6.96,2.81,;5.43,2.97,;4.81,1.55,;3.29,1.24,;2.26,2.38,;.76,2.06,;.27,.6,;1.32,-.56,;2.82,-.24,;-1.23,.27,;-1.72,-1.19,;-3.22,-1.5,;-4.25,-.36,;-5.77,-.69,;-5.77,-2.23,;-7.11,-3,;-8.44,-2.23,;-8.47,-.69,;-9.6,.35,;-8.98,1.77,;-7.42,1.58,;-7.12,.09,;5.95,.53,;5.95,-1.03,)| | ||
Structure |