Reaction Details |
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Target | Prostaglandin G/H synthase 2 |
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Ligand | BDBM50589580 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_2193818 (CHEMBL5106178) |
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IC50 | 320±n/a nM |
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Citation | Saletti, M; Maramai, S; Reale, A; Paolino, M; Brogi, S; Di Capua, A; Cappelli, A; Giorgi, G; D'Avino, D; Rossi, A; Ghelardini, C; Di Cesare Mannelli, L; Sardella, R; Carotti, A; Woelkart, G; Klösch, B; Bigogno, C; Dondio, G; Anzini, M Novel analgesic/anti-inflammatory agents: 1,5-Diarylpyrrole nitrooxyethyl sulfides and related compounds as Cyclooxygenase-2 inhibitors containing a nitric oxide donor moiety endowed with vasorelaxant properties. Eur J Med Chem241:0 (2022) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Prostaglandin G/H synthase 2 |
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Name: | Prostaglandin G/H synthase 2 |
Synonyms: | Cox-2 | Cox2 | Cyclooxygenase-2 | Cyclooxygenase-2 (COX-2) | Glucocorticoid-regulated inflammatory cyclooxygenase | Gripghs | Macrophage activation-associated marker protein P71/73 | PES-2 | PGH synthase 2 | PGH2_MOUSE | PGHS-2 | PHS II | Pghs-b | Prostaglandin G/H synthase (cyclooxygenase) | Prostaglandin H2 synthase 2 | Prostaglandin-endoperoxide synthase 2 | Ptgs2 | TIS10 protein | Tis10 |
Type: | Protein |
Mol. Mass.: | 69020.39 |
Organism: | Mus musculus (Mouse) |
Description: | Q05769 |
Residue: | 604 |
Sequence: | MLFRAVLLCAALGLSQAANPCCSNPCQNRGECMSTGFDQYKCDCTRTGFYGENCTTPEFL
TRIKLLLKPTPNTVHYILTHFKGVWNIVNNIPFLRSLIMKYVLTSRSYLIDSPPTYNVHY
GYKSWEAFSNLSYYTRALPPVADDCPTPMGVKGNKELPDSKEVLEKVLLRREFIPDPQGS
NMMFAFFAQHFTHQFFKTDHKRGPGFTRGLGHGVDLNHIYGETLDRQHKLRLFKDGKLKY
QVIGGEVYPPTVKDTQVEMIYPPHIPENLQFAVGQEVFGLVPGLMMYATIWLREHNRVCD
ILKQEHPEWGDEQLFQTSRLILIGETIKIVIEDYVQHLSGYHFKLKFDPELLFNQQFQYQ
NRIASEFNTLYHWHPLLPDTFNIEDQEYSFKQFLYNNSILLEHGLTQFVESFTRQIAGRV
AGGRNVPIAVQAVAKASIDQSREMKYQSLNEYRKRFSLKPYTSFEELTGEKEMAAELKAL
YSDIDVMELYPALLVEKPRPDAIFGETMVELGAPFSLKGLMGNPICSPQYWKPSTFGGEV
GFKIINTASIQSLICNNVKGCPFTSFNVQDPQPTKTATINASASHSRLDDINPTVLIKRR
STEL
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BDBM50589580 |
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n/a |
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Name | BDBM50589580 |
Synonyms: | CHEMBL5185512 |
Type | Small organic molecule |
Emp. Form. | C22H25NO4S2 |
Mol. Mass. | 431.568 |
SMILES | Cc1c(CC[S+]([O-])CCO)cc(-c2ccc(cc2)S(C)(=O)=O)n1-c1ccccc1 |
Structure |
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