| Reaction Details |
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 | Report a problem with these data |
| Target | Carbonic anhydrase 4 |
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| Ligand | BDBM50589823 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2194404 (CHEMBL5106764) |
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| Ki | 0.900000±n/a nM |
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| Citation |  Bonardi, A; Micheli, L; Di Cesare Mannelli, L; Ghelardini, C; Gratteri, P; Nocentini, A; Supuran, CT Development of Hydrogen Sulfide-Releasing Carbonic Anhydrases IX- and XII-Selective Inhibitors with Enhanced Antihyperalgesic Action in a Rat Model of Arthritis. J Med Chem65:13143-13157 (2022) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Carbonic anhydrase 4 |
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| Name: | Carbonic anhydrase 4 |
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| Synonyms: | CA-IV | CA4 | CAH4_HUMAN | Carbonate dehydratase IV | Carbonic anhydrase | Carbonic anhydrase 4 (CA IV) | Carbonic anhydrase IV (CA IV) |
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| Type: | Enzyme |
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| Mol. Mass.: | 35037.98 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P22748 |
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| Residue: | 312 |
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| Sequence: | MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTK
AKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSD
LPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGF
QPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFRE
PIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLG
PMLACLLAGFLR
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| BDBM50589823 |
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| n/a |
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| Name | BDBM50589823 |
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| Synonyms: | CHEMBL5199926 |
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| Type | Small organic molecule |
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| Emp. Form. | C15H17BrN2O2S |
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| Mol. Mass. | 369.277 |
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| SMILES | NS(=O)(=O)c1ccc(CCNCc2ccc(Br)cc2)cc1 |
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| Structure | 
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