| Reaction Details |
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 | Report a problem with these data |
| Target | Glycogen synthase kinase 3 |
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| Ligand | BDBM50259155 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2194693 (CHEMBL5107053) |
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| IC50 | 23±n/a nM |
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| Citation |  Galal, KA; Truong, A; Kwarcinski, F; de Silva, C; Avalani, K; Havener, TM; Chirgwin, ME; Merten, E; Ong, HW; Willis, C; Abdelwaly, A; Helal, MA; Derbyshire, ER; Zutshi, R; Drewry, DH Identification of Novel 2,4,5-Trisubstituted Pyrimidines as Potent Dual Inhibitors of Plasmodial J Med Chem65:13172-13197 (2022) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Glycogen synthase kinase 3 |
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| Name: | Glycogen synthase kinase 3 |
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| Synonyms: | n/a |
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| Type: | PROTEIN |
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| Mol. Mass.: | 51607.56 |
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| Organism: | Plasmodium falciparum (isolate 3D7) |
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| Description: | ChEMBL_749959 |
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| Residue: | 440 |
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| Sequence: | MKNWPIDEDINIYEEKNHTNNKNYVNNFEMSDQKDEEEYSHSSNRSEDEDEERTIDNEIN
RSPNKSYKLGNIIGNGSFGVVYEAICIDTSEQVAIKKVLQDPQYKNRELMIMKNLNHINI
IYLKDYYYTESFKKNEKNIFLNVVMEYIPQTVHKYMKYYSRNNQALPMFLVKLYSYQLCR
ALSYIHSKFICHRDLKPQNLLIDPRTHTLKLCDFGSAKNLLAGQRSVSYICSRFYRAPEL
MLGSTNYTTHIDLWSLGCIIAEMILGYPIFSGQSSVDQLVRIIQVLGTPTEDQLKEMNPN
YADIKFPDVKSKDLRKVFPKGTPDEAINLITQFLKYEPLKRLNPIEALADPFFDELRDPC
IKLPKYIDKLPELFNFCKEEIQEMSMECRRKIIPKNVYEEFLMVDENDNNIINDTISNDF
NESNLDTNNSNNKTHVIIES
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| BDBM50259155 |
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| n/a |
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| Name | BDBM50259155 |
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| Synonyms: | (Z)-Hymenialdisine | Hymenialdisine |
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| Type | Small organic molecule |
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| Emp. Form. | C11H10BrN5O2 |
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| Mol. Mass. | 324.133 |
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| SMILES | NC1=NC(=O)\C(N1)=C1/CCNC(=O)c2[nH]c(Br)cc12 |t:1| |
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| Structure | 
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