Ki Summary

Reaction Details

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Target

RNA-directed RNA polymerase

Ligand

BDBM50162111

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_306530 (CHEMBL829597)

IC50

372±n/a nM

Citation

Harper, S; Pacini, B; Avolio, S; Di Filippo, M; Migliaccio, G; Laufer, R; De Francesco, R; Rowley, M; Narjes, F Development and preliminary optimization of indole-N-acetamide inhibitors of hepatitis C virus NS5B polymerase. J Med Chem48:1314-7 (2005) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

RNA-directed RNA polymerase

Name:

RNA-directed RNA polymerase

Synonyms:

Hepatitis C virus NS5B RNA-dependent RNA polymerase | NS5B protein

Type:

Protein

Mol. Mass.:

25173.95

Organism:

Hepatitis C virus

Description:

Q8JXU8

Residue:

229

Sequence:

RTEEAIYQCCDLDPQARVAIRSLTERLYVGGPLTNSRGENCGYRRRASGVLTTSCGNTLT
CYIKAQAACRAAGRQDCTMLVCGDDLVVICESAGVQEDAASLRAFTEAMTRYSAPPGDPP
QPEYDLELITSCSSNVSVAHDGAGKRVYYLTRDPTTPLARAAWETARHTPVNSWLGNIIM
FAPTLWVRMIMLTHFFSVLIARDQLEQALDCEIYGACYSIEPLLPPIIQ

BDBM50162111

n/a

Name

BDBM50162111

Synonyms:

2-(2-Chloro-phenyl)-3-cyclohexyl-1-dimethylcarbamoylmethyl-1H-indole-6-carboxylic acid | CHEMBL369552

Type

Small organic molecule

Emp. Form.

C25H27ClN2O3

Mol. Mass.

438.946

SMILES

CN(C)C(=O)Cn1c(c(C2CCCCC2)c2ccc(cc12)C(O)=O)-c1ccccc1Cl |(-.96,6.24,;.05,5.1,;1.57,5.4,;-.41,3.65,;-1.93,3.33,;.61,2.49,;.12,1.04,;1.03,-.22,;.12,-1.45,;.52,-2.95,;-.55,-4.04,;-.16,-5.51,;1.34,-5.91,;2.43,-4.81,;2.01,-3.32,;-1.34,-.99,;-2.67,-1.76,;-4,-.99,;-4,.55,;-2.67,1.32,;-1.34,.55,;-5.36,1.32,;-6.69,.55,;-5.36,2.86,;2.57,-.05,;3.2,1.34,;4.74,1.49,;5.64,.23,;5,-1.19,;3.46,-1.31,;2.83,-2.71,)|

Structure