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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Protein arginine N-methyltransferase 5 | ||
| Ligand | BDBM50590527 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_2197017 (CHEMBL5109533) | ||
| IC50 | 5.0±n/a nM | ||
| Citation |  Smith, CR; Aranda, R; Christensen, JG; Engstrom, LD; Gunn, RJ; Ivetac, A; Ketcham, JM; Kuehler, J; David Lawson, J; Marx, MA; Olson, P; Thomas, NC; Wang, X; Waters, LM; Kulyk, S Design and evaluation of achiral, non-atropisomeric 4-(aminomethyl)phthalazin-1(2H)-one derivatives as novel PRMT5/MTA inhibitors. Bioorg Med Chem71:0 (2022) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Protein arginine N-methyltransferase 5 | |||
| Name: | Protein arginine N-methyltransferase 5 | ||
| Synonyms: | 72 kDa ICln-binding protein | ANM5_HUMAN | HRMT1L5 | Histone-arginine N-methyltransferase PRMT5 | IBP72 | JBP1 | Jak-binding protein 1 | PRMT5 | PRMT5/MEP50 complex | Protein arginine N-methyltransferase 5 (PRMT5) | Protein arginine methyltransferase 5 (PRMT5) | SKB1 | SKB1 homolog | SKB1Hs | Shk1 kinase-binding protein 1 homolog | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 72679.99 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | O14744 | ||
| Residue: | 637 | ||
| Sequence: |
| ||
| BDBM50590527 | |||
| n/a | |||
| Name | BDBM50590527 | ||
| Synonyms: | CHEMBL5176033 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C24H20N6O2S | ||
| Mol. Mass. | 456.52 | ||
| SMILES | COCc1cc(cc2c(CN)n[nH]c(=O)c12)-c1cnn(C)c1-c1sc2ccccc2c1C#N |(.78,-4.41,;.78,-2.87,;2.12,-2.1,;2.12,-.56,;.78,.2,;.78,1.75,;2.11,2.52,;3.44,1.75,;4.78,2.52,;4.78,4.06,;6.11,4.83,;6.11,1.75,;6.11,.21,;4.78,-.56,;4.78,-2.1,;3.44,.21,;-.55,2.52,;-.89,4.01,;-2.43,4.19,;-3.04,2.81,;-4.53,2.42,;-1.89,1.75,;-1.89,.21,;-.64,-.7,;-1.12,-2.16,;-.35,-3.49,;-1.12,-4.83,;-2.65,-4.83,;-3.43,-3.5,;-2.66,-2.16,;-3.13,-.7,;-4.62,-.3,;-6.11,.1,)| | ||
| Structure | 
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