Found 4956 hits with Last Name = 'marx' and Initial = 'ma' Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Son of sevenless homolog 1 [564-1049]
() | BDBM609525
(US11702418, Example 11-4)Show SMILES C[C@@H](Nc1nnc(C)c2ccc(cc12)N1CCN(CC1)C(=O)[C@@H]1CCOC1)c1cccc(c1C)C(F)(F)F |r| | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| | 0.0100 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2C251J6 |
More data for this Ligand-Target Pair | |
Son of sevenless homolog 1 [564-1049]
() | BDBM609452
(US11702418, Example 10-11)Show SMILES C[C@@H](Nc1nnc(C)c2ccc(cc12)N1CCn2c(C)nc(C)c2C1)c1cccc(c1C)C(F)(F)F |r| | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| | 0.0100 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2C251J6 |
More data for this Ligand-Target Pair | |
Son of sevenless homolog 1 [564-1049]
() | BDBM609451
(US11702418, Example 10-10)Show SMILES C[C@@H](Nc1nnc(C)c2ccc(cc12)N1CCN(CC1)c1cnn(C)c1)c1cccc(c1C)C(F)(F)F |r| | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| | 0.0100 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2C251J6 |
More data for this Ligand-Target Pair | |
Son of sevenless homolog 1 [564-1049]
() | BDBM609526
(US11702418, Example 11-5)Show SMILES C[C@@H](Nc1nnc(C)c2ccc(cc12)N1CCN(CC1)C(=O)[C@H]1CCOC1)c1cccc(c1C)C(F)(F)F |r| | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| | 0.0100 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2C251J6 |
More data for this Ligand-Target Pair | |
Son of sevenless homolog 1 [564-1049]
() | BDBM609446
(US11702418, Example 10-5)Show SMILES C[C@@H](Nc1nnc(C)c2ccc(cc12)N1CCNCC(F)(F)C1)c1cccc(c1C)C(F)(F)F |r| | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| | <0.0100 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2C251J6 |
More data for this Ligand-Target Pair | |
Son of sevenless homolog 1 [564-1049]
() | BDBM609524
(US11702418, Example 11-3)Show SMILES C[C@@H](Nc1nnc(C)c2ccc(cc12)N1CCN(CC1)C(=O)C1(CC1)C(F)(F)F)c1cccc(c1C)C(F)(F)F |r| | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| | <0.0100 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2C251J6 |
More data for this Ligand-Target Pair | |
Son of sevenless homolog 1 [564-1049]
() | BDBM609523
(US11702418, Example 11-2)Show SMILES C[C@@H](Nc1nnc(C)c2ccc(cc12)N1CCN(CC1)C(=O)C1CCOCC1)c1cccc(c1C)C(F)(F)F |r| | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| | <0.0100 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2C251J6 |
More data for this Ligand-Target Pair | |
Son of sevenless homolog 1 [564-1049]
() | BDBM609522
((R)-(4-(1-methyl-4-((1-(2-methyl-3-(trifluoromethy...)Show SMILES C[C@@H](Nc1nnc(C)c2ccc(cc12)N1CCN(CC1)C(=O)C1COC1)c1cccc(c1C)C(F)(F)F |r| | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| | 0.0100 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2C251J6 |
More data for this Ligand-Target Pair | |
Son of sevenless homolog 1 [564-1049]
() | BDBM609420
(US11702418, Example 6-10)Show SMILES C[C@@H](Nc1nnc(C)c2ccc(cc12)N1CCn2nccc2C1)c1cccc(c1C)C(F)(F)F |r| | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| | <0.0100 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2C251J6 |
More data for this Ligand-Target Pair | |
Son of sevenless homolog 1 [564-1049]
() | BDBM609413
(US11702418, Example 6-3)Show SMILES CNCc1ccccc1-c1ccc(s1)[C@@H](C)Nc1nnc(C)c2ccc(cc12)N1CCOCC1 |r| | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| | 0.0200 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2C251J6 |
More data for this Ligand-Target Pair | |
Son of sevenless homolog 1 [564-1049]
() | BDBM609450
(US11702418, Example 10-9)Show SMILES C[C@@H](Nc1nnc(C)c2ccc(cc12)N1CCC(C)(N)CC1)c1cccc(c1C)C(F)(F)F |r| | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| | 0.0500 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2C251J6 |
More data for this Ligand-Target Pair | |
Son of sevenless homolog 1 [564-1049]
() | BDBM609448
(US11702418, Example 10-7)Show SMILES CNC1CCN(CC1)c1ccc2c(C)nnc(N[C@H](C)c3cccc(c3C)C(F)(F)F)c2c1 |r| | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| | 0.0700 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2C251J6 |
More data for this Ligand-Target Pair | |
Son of sevenless homolog 1 [564-1049]
() | BDBM609445
(US11702418, Example 10-4)Show SMILES C[C@@H](Nc1nnc(C)c2ccc(cc12)N1CCNCC1)c1cccc(C(F)F)c1C |r| | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| | 0.0800 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2C251J6 |
More data for this Ligand-Target Pair | |
Son of sevenless homolog 1 [564-1049]
() | BDBM609449
(US11702418, Example 10-8)Show SMILES C[C@@H](Nc1nnc(C)c2ccc(cc12)N1CCC(CC1)N(C)C)c1cccc(c1C)C(F)(F)F |r| | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| | 0.0900 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2C251J6 |
More data for this Ligand-Target Pair | |
Son of sevenless homolog 1 [564-1049]
() | BDBM50601067
(CHEMBL5208088 | US11702418, Example 6-4)Show SMILES C[C@@H](Nc1nnc(C)c2ccc(cc12)N1CCNCC1)c1cccc(c1C)C(F)(F)F |r| | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| Purchase
MCE PC cid PC sid PDB UniChem
| PDB
| 0.110 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2C251J6 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Son of sevenless homolog 1 [564-1049]
() | BDBM609411
((R)-4-methyl-N-(1-(2-methyl-3-(trifluoromethyl)phe...)Show SMILES C[C@@H](Nc1nnc(C)c2ccc(cc12)N1CCN(C)CC1)c1cccc(c1C)C(F)(F)F |r| | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| MCE PC cid PC sid UniChem
| | 0.110 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2C251J6 |
More data for this Ligand-Target Pair | |
Son of sevenless homolog 1 [564-1049]
() | BDBM609416
(US11702418, Example 6-6)Show SMILES CNCc1c(F)cccc1-c1ccc(s1)[C@@H](C)Nc1nnc(C)c2ccc(cc12)N1CCOCC1 |r| | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| | 0.110 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2C251J6 |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
(Homo sapiens (Human)) | BDBM50428107
(CHEMBL2331664 | PF-04979064 | US8791131, 257)Show SMILES C[C@H](O)C(=O)N1CCC(CC1)n1c2c(cnc3ccc(nc23)-c2ccc(C)nc2)n(C)c1=O |r| Show InChI InChI=1S/C24H26N6O3/c1-14-4-5-16(12-25-14)18-6-7-19-21(27-18)22-20(13-26-19)28(3)24(33)30(22)17-8-10-29(11-9-17)23(32)15(2)31/h4-7,12-13,15,17,31H,8-11H2,1-3H3/t15-/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE MMDB PC cid PC sid PDB UniChem
Similars
| PDB Article PubMed
| 0.111 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description Inhibition of human PI3Kgamma |
ACS Med Chem Lett 4: 91-7 (2013)
Article DOI: 10.1021/ml300309h BindingDB Entry DOI: 10.7270/Q2HX1F0B |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Son of sevenless homolog 1 [564-1049]
() | BDBM609415
(US11702418, Example 6-5)Show SMILES C[C@@H](Nc1nnc(C)c2ccc(cc12)N1CCOCC1)c1cc(N)cc(c1)C(F)(F)F |r| | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| | 0.120 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2C251J6 |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
(Homo sapiens (Human)) | BDBM50428107
(CHEMBL2331664 | PF-04979064 | US8791131, 257)Show SMILES C[C@H](O)C(=O)N1CCC(CC1)n1c2c(cnc3ccc(nc23)-c2ccc(C)nc2)n(C)c1=O |r| Show InChI InChI=1S/C24H26N6O3/c1-14-4-5-16(12-25-14)18-6-7-19-21(27-18)22-20(13-26-19)28(3)24(33)30(22)17-8-10-29(11-9-17)23(32)15(2)31/h4-7,12-13,15,17,31H,8-11H2,1-3H3/t15-/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE MMDB PC cid PC sid PDB UniChem
Similars
| Article PubMed
| 0.122 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description Inhibition of human PI3Kdelta |
ACS Med Chem Lett 4: 91-7 (2013)
Article DOI: 10.1021/ml300309h BindingDB Entry DOI: 10.7270/Q2HX1F0B |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM50428107
(CHEMBL2331664 | PF-04979064 | US8791131, 257)Show SMILES C[C@H](O)C(=O)N1CCC(CC1)n1c2c(cnc3ccc(nc23)-c2ccc(C)nc2)n(C)c1=O |r| Show InChI InChI=1S/C24H26N6O3/c1-14-4-5-16(12-25-14)18-6-7-19-21(27-18)22-20(13-26-19)28(3)24(33)30(22)17-8-10-29(11-9-17)23(32)15(2)31/h4-7,12-13,15,17,31H,8-11H2,1-3H3/t15-/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE MMDB PC cid PC sid PDB UniChem
Similars
| Article PubMed
| 0.130 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description Inhibition of human PI3Kalpha |
ACS Med Chem Lett 4: 91-7 (2013)
Article DOI: 10.1021/ml300309h BindingDB Entry DOI: 10.7270/Q2HX1F0B |
More data for this Ligand-Target Pair | |
Son of sevenless homolog 1 [564-1049]
() | BDBM609387
(US11702418, Example 1-28)Show SMILES C[C@@H](Nc1nncc2ccc(cc12)N1CCn2c(C1)nc(C)c2C)c1cccc(c1C)C(F)(F)F |r| | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| | 0.170 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2C251J6 |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Mus musculus (Mouse)) | BDBM50428109
(CHEMBL2331668 | US8791131, 259)Show SMILES CC(=O)N1CCC(CC1)n1c2c(cnc3ccc(nc23)-c2cnc3[nH]ncc3c2)n(C)c1=O Show InChI InChI=1S/C23H22N8O2/c1-13(32)30-7-5-16(6-8-30)31-21-19(29(2)23(31)33)12-24-18-4-3-17(27-20(18)21)14-9-15-11-26-28-22(15)25-10-14/h3-4,9-12,16H,5-8H2,1-2H3,(H,25,26,28) | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 0.191 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description Inhibition of mouse PI3Kalpha |
ACS Med Chem Lett 4: 91-7 (2013)
Article DOI: 10.1021/ml300309h BindingDB Entry DOI: 10.7270/Q2HX1F0B |
More data for this Ligand-Target Pair | |
Son of sevenless homolog 1 [564-1049]
() | BDBM609528
((R)-4-methyl-7-(4-(1-methyl-1H-pyrazol-4-yl)pipera...)Show SMILES C[C@@H](Nc1nnc(C)c2cnc(cc12)N1CCN(CC1)c1cnn(C)c1)c1cccc(c1C)C(F)(F)F |r| | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| | 0.200 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2C251J6 |
More data for this Ligand-Target Pair | |
Son of sevenless homolog 1 [564-1049]
() | BDBM609468
(US11702418, Example 10-32)Show SMILES C[C@@H](Nc1nnc(C)c2ccc(cc12)N1C[C@H]2CC[C@@H]1CN2C)c1cccc(c1C)C(F)(F)F |r,TLB:22:21:14.15:17.18,THB:11:14:21.20:17.18| | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| | 0.200 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2C251J6 |
More data for this Ligand-Target Pair | |
Son of sevenless homolog 1 [564-1049]
() | BDBM609472
(US11702418, Example 10-36)Show SMILES C[C@@H](Nc1nnc(C)c2ccc(cc12)N1CCC2(CCNC2)CC1)c1cccc(c1C)C(F)(F)F |r| | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| | 0.230 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2C251J6 |
More data for this Ligand-Target Pair | |
Son of sevenless homolog 1 [564-1049]
() | BDBM609473
(US11702418, Example 10-37)Show SMILES C[C@@H](Nc1nnc(C)c2ccc(cc12)N1CCC2(CCN(C)C2)CC1)c1cccc(c1C)C(F)(F)F |r| | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| | 0.240 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2C251J6 |
More data for this Ligand-Target Pair | |
Son of sevenless homolog 1 [564-1049]
() | BDBM50601075
(CHEMBL5202472 | US11702418, Example 6-9)Show SMILES C[C@@H](Nc1nnc(C)c2cnc(cc12)N1CCNCC1)c1cccc(c1C)C(F)(F)F |r| | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| | 0.240 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2C251J6 |
More data for this Ligand-Target Pair | |
Serine/threonine-protein kinase mTOR
(Homo sapiens (Human)) | BDBM50428109
(CHEMBL2331668 | US8791131, 259)Show SMILES CC(=O)N1CCC(CC1)n1c2c(cnc3ccc(nc23)-c2cnc3[nH]ncc3c2)n(C)c1=O Show InChI InChI=1S/C23H22N8O2/c1-13(32)30-7-5-16(6-8-30)31-21-19(29(2)23(31)33)12-24-18-4-3-17(27-20(18)21)14-9-15-11-26-28-22(15)25-10-14/h3-4,9-12,16H,5-8H2,1-2H3,(H,25,26,28) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 0.243 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description Inhibition of mTOR (unknown origin) |
ACS Med Chem Lett 4: 91-7 (2013)
Article DOI: 10.1021/ml300309h BindingDB Entry DOI: 10.7270/Q2HX1F0B |
More data for this Ligand-Target Pair | |
Son of sevenless homolog 1 [564-1049]
() | BDBM609613
(US11702418, Example 12-89)Show SMILES C[C@@H](Nc1nnc(C)c2cnc(cc12)N1C[C@H]2CC[C@@H]1CN2CCO)c1cccc(C#N)c1C |r,TLB:22:21:14.15:17.18,THB:11:14:21.20:17.18| | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| | 0.25 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2C251J6 |
More data for this Ligand-Target Pair | |
Son of sevenless homolog 1 [564-1049]
() | BDBM609618
(US11702418, Example 12-102)Show SMILES CCN1CCN(CC1)c1cc2c(N[C@H](C)c3cccc(C(F)F)c3F)nnc(C)c2cn1 |r| | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| | 0.25 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2C251J6 |
More data for this Ligand-Target Pair | |
Son of sevenless homolog 1 [564-1049]
() | BDBM609585
(US11702418, Example 12-60)Show SMILES C[C@@H](Nc1nnc(C)c2cnc(cc12)N1C[C@H]2CC[C@@H]1CN2C)c1cccc(c1F)C(F)(F)F |r,TLB:22:21:14.15:17.18,THB:11:14:21.20:17.18| | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| | 0.25 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2C251J6 |
More data for this Ligand-Target Pair | |
Son of sevenless homolog 1 [564-1049]
() | BDBM609540
(US11702418, Example 12-15)Show SMILES C[C@@H](Nc1nnc(C)c2cnc(cc12)N1CCC(CC1)N(C)C)c1cccc(c1C)C(F)(F)F |r| | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| | 0.25 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2C251J6 |
More data for this Ligand-Target Pair | |
Son of sevenless homolog 1 [564-1049]
() | BDBM609394
(US11702418, Example 1-37)Show SMILES C[C@@H](Nc1nncc2ccc(cc12)N1CCn2c(C)ncc2C1)c1cccc(c1C)C(F)(F)F |r| | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| | 0.25 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2C251J6 |
More data for this Ligand-Target Pair | |
Son of sevenless homolog 1 [564-1049]
() | BDBM609397
(US11702418, Example 1-40)Show SMILES C[C@@H](Nc1nncc2ccc(cc12)N1CCn2cc(C)nc2C1)c1cccc(c1C)C(F)(F)F |r| | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| | 0.270 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2C251J6 |
More data for this Ligand-Target Pair | |
Son of sevenless homolog 1 [564-1049]
() | BDBM609457
(US11702418, Example 10-19)Show SMILES C[C@@H](Nc1nnc(C)c2ccc(cc12)N1CCC2(CCCN2C)CC1)c1cccc(c1C)C(F)(F)F |r| | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| | 0.280 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2C251J6 |
More data for this Ligand-Target Pair | |
Son of sevenless homolog 1 [564-1049]
() | BDBM609424
(US11702418, Example 6-13)Show SMILES CNCc1c(F)cccc1-c1ccc(s1)[C@@H](C)Nc1nnc(C)c2cnc(cc12)N1CCOCC1 |r| | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| | 0.290 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2C251J6 |
More data for this Ligand-Target Pair | |
Son of sevenless homolog 1 [564-1049]
() | BDBM50601069
(CHEMBL5191446 | US11702418, Example 6-7)Show SMILES C[C@@H](Nc1nnc(C)c2ccc(cc12)N1CCN(C)C(=O)C1)c1cccc(c1C)C(F)(F)F |r| | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| | 0.290 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2C251J6 |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Mus musculus (Mouse)) | BDBM50428107
(CHEMBL2331664 | PF-04979064 | US8791131, 257)Show SMILES C[C@H](O)C(=O)N1CCC(CC1)n1c2c(cnc3ccc(nc23)-c2ccc(C)nc2)n(C)c1=O |r| Show InChI InChI=1S/C24H26N6O3/c1-14-4-5-16(12-25-14)18-6-7-19-21(27-18)22-20(13-26-19)28(3)24(33)30(22)17-8-10-29(11-9-17)23(32)15(2)31/h4-7,12-13,15,17,31H,8-11H2,1-3H3/t15-/m0/s1 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| Purchase
CHEMBL MCE MMDB PC cid PC sid PDB UniChem
Similars
| Article PubMed
| 0.299 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description Inhibition of mouse PI3Kalpha |
ACS Med Chem Lett 4: 91-7 (2013)
Article DOI: 10.1021/ml300309h BindingDB Entry DOI: 10.7270/Q2HX1F0B |
More data for this Ligand-Target Pair | |
Son of sevenless homolog 1 [564-1049]
() | BDBM609558
(US11702418, Example 12-33)Show SMILES C[C@@H](Nc1nnc(C)c2cnc(cc12)N1CCC(CC1)N1CCC1)c1cccc(c1C)C(F)(F)F |r| | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| | 0.300 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2C251J6 |
More data for this Ligand-Target Pair | |
Son of sevenless homolog 1 [564-1049]
() | BDBM609456
(US11702418, Example 10-18 | US11702418, Example 10...)Show SMILES C[C@@H](Nc1nnc(C)c2ccc(cc12)N1CCC2(CCCN2)CC1)c1cccc(c1C)C(F)(F)F |r| | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| | 0.310 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2C251J6 |
More data for this Ligand-Target Pair | |
Son of sevenless homolog 1 [564-1049]
() | BDBM609478
(US11702418, Example 10-42)Show SMILES C[C@@H](Nc1nnc(C)c2ccc(cc12)N1CCC(C)(CC1)N(C)C)c1cccc(c1C)C(F)(F)F |r| | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| | 0.310 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2C251J6 |
More data for this Ligand-Target Pair | |
Son of sevenless homolog 1 [564-1049]
() | BDBM609433
(US11702418, Example 7-3)Show SMILES C[C@@H](Nc1nnc(C)c2ccc(O[C@H]3CCNC3)cc12)c1cccc(c1C)C(F)(F)F |r| | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| | 0.320 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2C251J6 |
More data for this Ligand-Target Pair | |
Son of sevenless homolog 1
(Homo sapiens (Human)) | BDBM50601067
(CHEMBL5208088 | US11702418, Example 6-4)Show SMILES C[C@@H](Nc1nnc(C)c2ccc(cc12)N1CCNCC1)c1cccc(c1C)C(F)(F)F |r| | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| Purchase
MCE PC cid PC sid PDB UniChem
| PDB Article PubMed
| 0.330 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.2c00741 BindingDB Entry DOI: 10.7270/Q2XD15Q0 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Son of sevenless homolog 1 [564-1049]
() | BDBM609432
(US11702418, Example 7-2)Show SMILES C[C@@H](Nc1nnc(C)c2ccc(OC3CCNCC3)cc12)c1cccc(c1C)C(F)(F)F |r| | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| | 0.330 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2C251J6 |
More data for this Ligand-Target Pair | |
Son of sevenless homolog 1 [564-1049]
() | BDBM609467
(US11702418, Example 10-31)Show SMILES C[C@@H](Nc1nnc(C)c2ccc(cc12)N1C[C@@H]2CC[C@H]1CN2C)c1cccc(c1C)C(F)(F)F |r,TLB:22:21:14.15:17.18,THB:11:14:21.20:17.18| | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| | 0.350 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2C251J6 |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM50380320
(CHEMBL2017653)Show SMILES Clc1ccc(-c2c(sc(N3CCOCC3)c2C#N)-c2nnc[nH]2)c(Cl)c1 |(13.97,-25.89,;13.2,-24.55,;13.97,-23.21,;13.2,-21.89,;11.67,-21.88,;10.91,-20.55,;11.39,-19.08,;10.14,-18.17,;8.88,-19.08,;7.54,-18.32,;7.53,-16.78,;6.2,-16.02,;4.87,-16.79,;4.88,-18.33,;6.21,-19.1,;9.36,-20.55,;8.46,-21.8,;7.56,-23.05,;12.84,-18.6,;14.09,-19.51,;15.33,-18.61,;14.86,-17.14,;13.32,-17.14,;10.89,-23.21,;9.36,-23.21,;11.66,-24.55,)| Show InChI InChI=1S/C17H13Cl2N5OS/c18-10-1-2-11(13(19)7-10)14-12(8-20)17(24-3-5-25-6-4-24)26-15(14)16-21-9-22-23-16/h1-2,7,9H,3-6H2,(H,21,22,23) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 0.350 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition of PI3Kalpha |
ACS Med Chem Lett 2: 809-813 (2011)
Article DOI: 10.1021/ml200126j BindingDB Entry DOI: 10.7270/Q2DJ5GN2 |
More data for this Ligand-Target Pair | |
Son of sevenless homolog 1 [564-1049]
() | BDBM609591
(US11702418, Example 12-67)Show SMILES C[C@@H](Nc1nnc(C)c2cnc(cc12)N1CCN(C)CC1)c1cccc(c1F)C(F)(F)F |r| | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| | 0.360 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2C251J6 |
More data for this Ligand-Target Pair | |
Son of sevenless homolog 1
(Homo sapiens (Human)) | BDBM50601075
(CHEMBL5202472 | US11702418, Example 6-9)Show SMILES C[C@@H](Nc1nnc(C)c2cnc(cc12)N1CCNCC1)c1cccc(c1C)C(F)(F)F |r| | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| 0.360 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.2c00741 BindingDB Entry DOI: 10.7270/Q2XD15Q0 |
More data for this Ligand-Target Pair | |
Son of sevenless homolog 1 [564-1049]
() | BDBM609592
(US11702418, Example 12-68)Show SMILES CCN1CCN(CC1)c1cc2c(N[C@H](C)c3cccc(c3F)C(F)(F)F)nnc(C)c2cn1 |r| | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| | 0.370 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2C251J6 |
More data for this Ligand-Target Pair | |