Ki Summary

Reaction Details

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Target

5-hydroxytryptamine receptor 1A

Ligand

BDBM50590636

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_2197348 (CHEMBL5109864)

0.900000±n/a nM

Citation

Fu, H; Rong, J; Chen, Z; Zhou, J; Collier, T; Liang, SH Positron Emission Tomography (PET) Imaging Tracers for Serotonin Receptors. J Med Chem65:10755-10808 (2022) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

5-hydroxytryptamine receptor 1A

Name:

5-hydroxytryptamine receptor 1A

Synonyms:

Type:

n/a

Mol. Mass.:

46122.49

Organism:

Homo sapiens (Human)

Description:

n/a

Residue:

422

Sequence:

MDVLSPGQGNNTTSPPAPFETGGNTTGISDVTVSYQVITSLLLGTLIFCAVLGNACVVAA
IALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCC
TSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPED
RSDPDACTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVKKVEKTGADT
RHGASPAPQPKKSVNGESGSRNWRLGVESKAGGALCANGAVRQGDDGAALEVIEVHRVGN
SKEHLPLPSEAGPTPCAPASFERKNERNAEAKRKMALARERKTVKTLGIIMGTFILCWLP
FFIVALVLPFCESSCHMPTLLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKFC
RQ

BDBM50590636

n/a

Name

BDBM50590636

Synonyms:

CHEMBL5199056

Type

Small organic molecule

Emp. Form.

C26H35FN4O2

Mol. Mass.

453.5826

SMILES

COc1ccccc1N1CCN(CCN(C(=O)[C@H]2CC[C@H](C[18F])CC2)c2ccccn2)CC1 |r,wU:20.21,wD:17.17,(-8.67,.39,;-7.33,-.38,;-7.33,-1.92,;-8.67,-2.69,;-8.67,-4.23,;-7.34,-5,;-6,-4.23,;-6,-2.69,;-4.67,-1.92,;-4.67,-.38,;-3.33,.39,;-2,-.38,;-.67,.39,;.67,-.38,;2,.39,;3.33,-.38,;3.33,-1.92,;4.67,.39,;6,-.38,;7.33,.38,;7.33,1.92,;8.67,2.69,;8.67,4.24,;6,2.7,;4.67,1.93,;2,1.93,;.67,2.7,;.67,4.23,;2,5,;3.33,4.24,;3.34,2.7,;-2,-1.92,;-3.33,-2.69,)|

Structure