Reaction Details |
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Target | LIM domain kinase 2 |
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Ligand | BDBM50299586 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_2199835 (CHEMBL5112351) |
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IC50 | 21±n/a nM |
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Citation | Collins, R; Lee, H; Jones, DH; Elkins, JM; Gillespie, JA; Thomas, C; Baldwin, AG; Jones, K; Waters, L; Paine, M; Atack, JR; Ward, SE; Grubisha, O; Foley, DW Comparative Analysis of Small-Molecule LIMK1/2 Inhibitors: Chemical Synthesis, Biochemistry, and Cellular Activity. J Med Chem65:13705-13713 (2022) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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LIM domain kinase 2 |
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Name: | LIM domain kinase 2 |
Synonyms: | LIMK2 | LIMK2_HUMAN |
Type: | PROTEIN |
Mol. Mass.: | 72238.81 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_1514398 |
Residue: | 638 |
Sequence: | MSALAGEDVWRCPGCGDHIAPSQIWYRTVNETWHGSCFRCSECQDSLTNWYYEKDGKLYC
PKDYWGKFGEFCHGCSLLMTGPFMVAGEFKYHPECFACMSCKVIIEDGDAYALVQHATLY
CGKCHNEVVLAPMFERLSTESVQEQLPYSVTLISMPATTEGRRGFSVSVESACSNYATTV
QVKEVNRMHISPNNRNAIHPGDRILEINGTPVRTLRVEEVEDAISQTSQTLQLLIEHDPV
SQRLDQLRLEARLAPHMQNAGHPHALSTLDTKENLEGTLRRRSLRRSNSISKSPGPSSPK
EPLLFSRDISRSESLRCSSSYSQQIFRPCDLIHGEVLGKGFFGQAIKVTHKATGKVMVMK
ELIRCDEETQKTFLTEVKVMRSLDHPNVLKFIGVLYKDKKLNLLTEYIEGGTLKDFLRSM
DPFPWQQKVRFAKGIASGMAYLHSMCIIHRDLNSHNCLIKLDKTVVVADFGLSRLIVEER
KRAPMEKATTKKRTLRKNDRKKRYTVVGNPYWMAPEMLNGKSYDETVDIFSFGIVLCEII
GQVYADPDCLPRTLDFGLNVKLFWEKFVPTDCPPAFFPLAAICCRLEPESRPAFSKLEDS
FEALSLYLGELGIPLPAELEELDHTVSMQYGLTRDSPP
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BDBM50299586 |
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n/a |
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Name | BDBM50299586 |
Synonyms: | (S)-3-(2-methyl-4-(5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperazine-1-carboxamido)phenyl dimethylcarbamate | CHEMBL570116 |
Type | Small organic molecule |
Emp. Form. | C22H27N7O3 |
Mol. Mass. | 437.4949 |
SMILES | C[C@H]1CN(CCN1C(=O)Nc1cccc(OC(=O)N(C)C)c1)c1ncnc2[nH]cc(C)c12 |r| |
Structure |
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