Reaction Details |
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Target | LIM domain kinase 2 |
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Ligand | BDBM50112355 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_2199837 (CHEMBL5112353) |
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IC50 | 39±n/a nM |
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Citation | Collins, R; Lee, H; Jones, DH; Elkins, JM; Gillespie, JA; Thomas, C; Baldwin, AG; Jones, K; Waters, L; Paine, M; Atack, JR; Ward, SE; Grubisha, O; Foley, DW Comparative Analysis of Small-Molecule LIMK1/2 Inhibitors: Chemical Synthesis, Biochemistry, and Cellular Activity. J Med Chem65:13705-13713 (2022) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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LIM domain kinase 2 |
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Name: | LIM domain kinase 2 |
Synonyms: | LIMK2 | LIMK2_HUMAN |
Type: | PROTEIN |
Mol. Mass.: | 72238.81 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_1514398 |
Residue: | 638 |
Sequence: | MSALAGEDVWRCPGCGDHIAPSQIWYRTVNETWHGSCFRCSECQDSLTNWYYEKDGKLYC
PKDYWGKFGEFCHGCSLLMTGPFMVAGEFKYHPECFACMSCKVIIEDGDAYALVQHATLY
CGKCHNEVVLAPMFERLSTESVQEQLPYSVTLISMPATTEGRRGFSVSVESACSNYATTV
QVKEVNRMHISPNNRNAIHPGDRILEINGTPVRTLRVEEVEDAISQTSQTLQLLIEHDPV
SQRLDQLRLEARLAPHMQNAGHPHALSTLDTKENLEGTLRRRSLRRSNSISKSPGPSSPK
EPLLFSRDISRSESLRCSSSYSQQIFRPCDLIHGEVLGKGFFGQAIKVTHKATGKVMVMK
ELIRCDEETQKTFLTEVKVMRSLDHPNVLKFIGVLYKDKKLNLLTEYIEGGTLKDFLRSM
DPFPWQQKVRFAKGIASGMAYLHSMCIIHRDLNSHNCLIKLDKTVVVADFGLSRLIVEER
KRAPMEKATTKKRTLRKNDRKKRYTVVGNPYWMAPEMLNGKSYDETVDIFSFGIVLCEII
GQVYADPDCLPRTLDFGLNVKLFWEKFVPTDCPPAFFPLAAICCRLEPESRPAFSKLEDS
FEALSLYLGELGIPLPAELEELDHTVSMQYGLTRDSPP
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BDBM50112355 |
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n/a |
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Name | BDBM50112355 |
Synonyms: | CHEMBL3609326 |
Type | Small organic molecule |
Emp. Form. | C25H23Cl2FN6O |
Mol. Mass. | 513.394 |
SMILES | CCn1c2nc(Nc3ccc(N4CCNCC4)c(F)c3)ncc2cc(-c2ccc(Cl)cc2Cl)c1=O |
Structure |
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