| Reaction Details |
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 | Report a problem with these data |
| Target | LIM domain kinase 2 |
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| Ligand | BDBM50591314 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2199837 (CHEMBL5112353) |
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| IC50 | 93±n/a nM |
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| Citation |  Collins, R; Lee, H; Jones, DH; Elkins, JM; Gillespie, JA; Thomas, C; Baldwin, AG; Jones, K; Waters, L; Paine, M; Atack, JR; Ward, SE; Grubisha, O; Foley, DW Comparative Analysis of Small-Molecule LIMK1/2 Inhibitors: Chemical Synthesis, Biochemistry, and Cellular Activity. J Med Chem65:13705-13713 (2022) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| LIM domain kinase 2 |
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| Name: | LIM domain kinase 2 |
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| Synonyms: | LIMK2 | LIMK2_HUMAN |
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| Type: | PROTEIN |
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| Mol. Mass.: | 72238.81 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1514398 |
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| Residue: | 638 |
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| Sequence: | MSALAGEDVWRCPGCGDHIAPSQIWYRTVNETWHGSCFRCSECQDSLTNWYYEKDGKLYC
PKDYWGKFGEFCHGCSLLMTGPFMVAGEFKYHPECFACMSCKVIIEDGDAYALVQHATLY
CGKCHNEVVLAPMFERLSTESVQEQLPYSVTLISMPATTEGRRGFSVSVESACSNYATTV
QVKEVNRMHISPNNRNAIHPGDRILEINGTPVRTLRVEEVEDAISQTSQTLQLLIEHDPV
SQRLDQLRLEARLAPHMQNAGHPHALSTLDTKENLEGTLRRRSLRRSNSISKSPGPSSPK
EPLLFSRDISRSESLRCSSSYSQQIFRPCDLIHGEVLGKGFFGQAIKVTHKATGKVMVMK
ELIRCDEETQKTFLTEVKVMRSLDHPNVLKFIGVLYKDKKLNLLTEYIEGGTLKDFLRSM
DPFPWQQKVRFAKGIASGMAYLHSMCIIHRDLNSHNCLIKLDKTVVVADFGLSRLIVEER
KRAPMEKATTKKRTLRKNDRKKRYTVVGNPYWMAPEMLNGKSYDETVDIFSFGIVLCEII
GQVYADPDCLPRTLDFGLNVKLFWEKFVPTDCPPAFFPLAAICCRLEPESRPAFSKLEDS
FEALSLYLGELGIPLPAELEELDHTVSMQYGLTRDSPP
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| BDBM50591314 |
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| n/a |
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| Name | BDBM50591314 |
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| Synonyms: | CHEMBL5202859 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H22ClN5O4 |
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| Mol. Mass. | 479.916 |
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| SMILES | CN1c2ccc(Cl)cc2OC[C@H](N2CCc3c(nn(Cc4ccccc4)c3C(N)=O)C2=O)C1=O |r| |
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| Structure | 
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