| Reaction Details |
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 | Report a problem with these data |
| Target | Somatostatin receptor type 5 |
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| Ligand | BDBM50592198 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2203288 (CHEMBL5115996) |
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| EC50 | 0.650000±n/a nM |
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| Citation |  Zhao, J; Wang, S; Hee Kim, S; Han, S; Rico-Bautista, E; Sturchler, E; Nguyen, J; Tan, H; Staley, C; Karin Kusnetzow, A; Betz, SF; Johns, M; Goulet, L; Luo, R; Fowler, M; Athanacio, J; Markison, S; Scott Struthers, R; Zhu, Y Discovery of 4-(3-aminopyrrolidinyl)-3-aryl-5-(benzimidazol-2-yl)-pyridines as potent and selective SST5 agonists for the treatment of congenital hyperinsulinism. Bioorg Med Chem Lett71:0 (2022) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Somatostatin receptor type 5 |
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| Name: | Somatostatin receptor type 5 |
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| Synonyms: | SOMATOSTATIN SST5 | SS-5-R | SS5-R | SS5R | SSR5_HUMAN | SSTR5 | Somatostatin receptor type 5 (SSTR5) |
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| Type: | Enzyme |
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| Mol. Mass.: | 39218.02 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P35346 |
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| Residue: | 364 |
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| Sequence: | MEPLFPASTPSWNASSPGAASGGGDNRTLVGPAPSAGARAVLVPVLYLLVCAAGLGGNTL
VIYVVLRFAKMKTVTNIYILNLAVADVLYMLGLPFLATQNAASFWPFGPVLCRLVMTLDG
VNQFTSVFCLTVMSVDRYLAVVHPLSSARWRRPRVAKLASAAAWVLSLCMSLPLLVFADV
QEGGTCNASWPEPVGLWGAVFIIYTAVLGFFAPLLVICLCYLLIVVKVRAAGVRVGCVRR
RSERKVTRMVLVVVLVFAGCWLPFFTVNIVNLAVALPQEPASAGLYFFVVILSYANSCAN
PVLYGFLSDNFRQSFQKVLCLRKGSGAKDADATEPRPDRIRQQQEATPPAHRAAANGLMQ
TSKL
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| BDBM50592198 |
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| n/a |
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| Name | BDBM50592198 |
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| Synonyms: | CHEMBL5200076 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H20F2N6 |
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| Mol. Mass. | 430.4526 |
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| SMILES | Cc1c(F)ccc2[nH]c(nc12)-c1cncc(-c2cc(F)cc(c2)C#N)c1N1CC[C@H](N)C1 |r| |
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| Structure | 
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