| Reaction Details |
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 | Report a problem with these data |
| Target | Potassium voltage-gated channel subfamily KQT member 5 |
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| Ligand | BDBM50592355 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2203876 (CHEMBL5116584) |
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| EC50 | 3780±n/a nM |
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| Citation |  Hernandez, CC; Tarfa, RA; Miguel I Limcaoco, J; Liu, R; Mondal, P; Hill, C; Keith Duncan, R; Tzounopoulos, T; Stephenson, CRJ; O'Meara, MJ; Wipf, P Development of an automated screen for Kv7.2 potassium channels and discovery of a new agonist chemotype. Bioorg Med Chem Lett71:0 (2022) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Potassium voltage-gated channel subfamily KQT member 5 |
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| Name: | Potassium voltage-gated channel subfamily KQT member 5 |
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| Synonyms: | KCNQ (Kv7) potassium channel | KCNQ5 | KCNQ5_HUMAN | Voltage-gated potassium channel subunit Kv7.5 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 102221.23 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_938650 |
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| Residue: | 932 |
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| Sequence: | MPRHHAGGEEGGAAGLWVKSGAAAAAAGGGRLGSGMKDVESGRGRVLLNSAAARGDGLLL
LGTRAATLGGGGGGLRESRRGKQGARMSLLGKPLSYTSSQSCRRNVKYRRVQNYLYNVLE
RPRGWAFIYHAFVFLLVFGCLILSVFSTIPEHTKLASSCLLILEFVMIVVFGLEFIIRIW
SAGCCCRYRGWQGRLRFARKPFCVIDTIVLIASIAVVSAKTQGNIFATSALRSLRFLQIL
RMVRMDRRGGTWKLLGSVVYAHSKELITAWYIGFLVLIFSSFLVYLVEKDANKEFSTYAD
ALWWGTITLTTIGYGDKTPLTWLGRLLSAGFALLGISFFALPAGILGSGFALKVQEQHRQ
KHFEKRRNPAANLIQCVWRSYAADEKSVSIATWKPHLKALHTCSPTKKEQGEASSSQKLS
FKERVRMASPRGQSIKSRQASVGDRRSPSTDITAEGSPTKVQKSWSFNDRTRFRPSLRLK
SSQPKPVIDADTALGTDDVYDEKGCQCDVSVEDLTPPLKTVIRAIRIMKFHVAKRKFKET
LRPYDVKDVIEQYSAGHLDMLCRIKSLQTRVDQILGKGQITSDKKSREKITAEHETTDDL
SMLGRVVKVEKQVQSIESKLDCLLDIYQQVLRKGSASALALASFQIPPFECEQTSDYQSP
VDSKDLSGSAQNSGCLSRSTSANISRGLQFILTPNEFSAQTFYALSPTMHSQATQVPISQ
SDGSAVAATNTIANQINTAPKPAAPTTLQIPPPLPAIKHLPRPETLHPNPAGLQESISDV
TTCLVASKENVQVAQSNLTKDRSMRKSFDMGGETLLSVCPMVPKDLGKSLSVQNLIRSTE
ELNIQLSGSESSGSRGSQDFYPKWRESKLFITDEEVGPEETETDTFDAAPQPAREAAFAS
DSLRTGRSRSSQSICKAGESTDALSLPHVKLK
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| BDBM50592355 |
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| n/a |
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| Name | BDBM50592355 |
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| Synonyms: | CHEMBL5200636 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H13F7N4O2 |
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| Mol. Mass. | 438.2995 |
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| SMILES | Nc1c(F)c(NCc2ncc(cc2F)C(F)(F)F)c(F)c(F)c1NC(=O)OC1CC1 |
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| Structure | 
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