| Reaction Details |
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 | Report a problem with these data |
| Target | Mitogen-activated protein kinase 10 |
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| Ligand | BDBM50592470 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2204354 (CHEMBL5117062) |
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| IC50 | 370±n/a nM |
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| Citation |  Abu Rabah, RR; Sebastian, A; Vunnam, S; Sultan, S; Tarazi, H; Anbar, HS; Shehata, MK; Zaraei, SO; Elgendy, SM; Al Shamma, SA; Omar, HA; Al-Tel, TH; El-Gamal, MI Design, synthesis, and biological evaluation of a new series of pyrazole derivatives: Discovery of potent and selective JNK3 kinase inhibitors. Bioorg Med Chem69:0 (2022) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Mitogen-activated protein kinase 10 |
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| Name: | Mitogen-activated protein kinase 10 |
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| Synonyms: | JNK3 | JNK3A | MAP kinase p49 3F12 | MAPK10 | MK10_HUMAN | Mitogen-Activated Protein Kinase 10 (JNK3) | Mitogen-activated protein kinase 10 (Stress-activated protein kinase JNK3) (c-Jun N-terminal kinase 3) (MAP kinase p49 3F12) | Mitogen-activated protein kinase 10/Receptor-interacting serine/threonine-protein kinase 1 | PRKM10 | SAPK1B | Stress-activated protein kinase JNK3 | c-Jun N-terminal kinase 3 (JNK3) |
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| Type: | Enzyme |
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| Mol. Mass.: | 52586.89 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 464 |
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| Sequence: | MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTV
LKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNH
KNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHL
HSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGY
KENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVEN
RPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYIN
VWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAA
VNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR
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| BDBM50592470 |
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| n/a |
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| Name | BDBM50592470 |
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| Synonyms: | CHEMBL5189795 | US20240002365, Compound CTx-0294885 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H24ClN7O |
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| Mol. Mass. | 437.925 |
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| SMILES | CNC(=O)c1ccccc1Nc1nc(Nc2ccc(cc2)N2CCNCC2)ncc1Cl |
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| Structure | 
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