Reaction Details |
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Target | Orexin/Hypocretin receptor type 1 |
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Ligand | BDBM50592802 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_2205644 (CHEMBL5118352) |
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Ki | 15±n/a nM |
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Citation | Saitoh, T; Amezawa, M; Horiuchi, J; Nagumo, Y; Yamamoto, N; Kutsumura, N; Ohshita, R; Tokuda, A; Irukayama-Tomobe, Y; Ogawa, Y; Ishikawa, Y; Hasegawa, E; Sakurai, T; Uchida, Y; Sato, T; Gouda, H; Tanimura, R; Yanagisawa, M; Nagase, H Discovery of novel orexin receptor antagonists using a 1,3,5-trioxazatriquinane bearing multiple effective residues (TriMER) library. Eur J Med Chem240:0 (2022) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Orexin/Hypocretin receptor type 1 |
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Name: | Orexin/Hypocretin receptor type 1 |
Synonyms: | HCRTR1 | Hypocretin receptor type 1 | OX1R_HUMAN | Orexin receptor type 1 | Orexin receptor type 1 (OR 1) | Orexin receptor type 1 (OR-1) | Orexin receptor type 1 (OX1) | Orexin receptor type 1 (OX1R) | Orexin receptor type 1 (OxR1) | Ox1r |
Type: | Protein |
Mol. Mass.: | 47554.50 |
Organism: | Homo sapiens (Human) |
Description: | O43613 |
Residue: | 425 |
Sequence: | MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVA
LVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCK
VIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQA
AVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFR
KLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKML
MVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNF
LSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSV
TTVLP
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BDBM50592802 |
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n/a |
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Name | BDBM50592802 |
Synonyms: | CHEMBL5175830 |
Type | Small organic molecule |
Emp. Form. | C32H29N5O5 |
Mol. Mass. | 563.6032 |
SMILES | [H][C@]12CO[C@]3([H])N1[C@@]([H])(O[C@@]3(C)c1cccc(NC(=O)c3ccccn3)c1)[C@@](C)(O2)c1cccc(NC(=O)c2ccccn2)c1 |r| |
Structure |
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