| Reaction Details |
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 | Report a problem with these data |
| Target | N-terminal Xaa-Pro-Lys N-methyltransferase 1 |
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| Ligand | BDBM60981 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2207099 (CHEMBL5119807) |
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| IC50 | 460±n/a nM |
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| Citation |  Dong, G; Deng, Y; Yasgar, A; Yadav, R; Talley, D; Zakharov, AV; Jain, S; Rai, G; Noinaj, N; Simeonov, A; Huang, R Venglustat Inhibits Protein N-Terminal Methyltransferase 1 in a Substrate-Competitive Manner. J Med Chem65:12334-12345 (2022) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| N-terminal Xaa-Pro-Lys N-methyltransferase 1 |
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| Name: | N-terminal Xaa-Pro-Lys N-methyltransferase 1 |
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| Synonyms: | 2.1.1.244 | Alpha N-terminal protein methyltransferase 1A | C9orf32 | METTL11A | Methyltransferase-like protein 11A | N-terminal RCC1 methyltransferase | N-terminal Xaa-Pro-Lys N-methyltransferase 1 | N-terminal Xaa-Pro-Lys N-methyltransferase 1, N-terminally processed | NRMT | NRMT1 | NRMT1 | NTM1A | NTM1A_HUMAN | NTMT1 | X-Pro-Lys N-terminal protein methyltransferase 1A |
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| Type: | PROTEIN |
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| Mol. Mass.: | 25382.72 |
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| Organism: | Homo sapiens |
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| Description: | ChEMBL_119192 |
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| Residue: | 223 |
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| Sequence: | MTSEVIEDEKQFYSKAKTYWKQIPPTVDGMLGGYGHISSIDINSSRKFLQRFLREGPNKT
GTSCALDCGAGIGRITKRLLLPLFREVDMVDITEDFLVQAKTYLGEEGKRVRNYFCCGLQ
DFTPEPDSYDVIWIQWVIGHLTDQHLAEFLRRCKGSLRPNGIIVIKDNMAQEGVILDDVD
SSVCRDLDVVRRIICSAGLSLLAEERQENLPDEIYHVYSFALR
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| BDBM60981 |
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| n/a |
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| Name | BDBM60981 |
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| Synonyms: | (2,3-diphenyl-1,2,4-thiadiazol-5-ylidene)-methyl-amine;hydrobromide | CHEMBL161867 | MLS002153327 | N-methyl-2,3-diphenyl-1,2,4-thiadiazol-5-imine;hydrobromide | SCH-202676 hydrobromide | SMR001230740 | cid_11957689 |
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| Type | Small organic molecule |
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| Emp. Form. | C15H13N3S |
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| Mol. Mass. | 267.349 |
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| SMILES | C\N=c1/nc(-c2ccccc2)n(s1)-c1ccccc1 |
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| Structure | 
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