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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | N-terminal Xaa-Pro-Lys N-methyltransferase 1 | ||
| Ligand | BDBM50593134 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_2207109 (CHEMBL5119817) | ||
| IC50 | >100000±n/a nM | ||
| Citation |  Dong, G; Deng, Y; Yasgar, A; Yadav, R; Talley, D; Zakharov, AV; Jain, S; Rai, G; Noinaj, N; Simeonov, A; Huang, R Venglustat Inhibits Protein N-Terminal Methyltransferase 1 in a Substrate-Competitive Manner. J Med Chem65:12334-12345 (2022) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| N-terminal Xaa-Pro-Lys N-methyltransferase 1 | |||
| Name: | N-terminal Xaa-Pro-Lys N-methyltransferase 1 | ||
| Synonyms: | 2.1.1.244 | Alpha N-terminal protein methyltransferase 1A | C9orf32 | METTL11A | Methyltransferase-like protein 11A | N-terminal RCC1 methyltransferase | N-terminal Xaa-Pro-Lys N-methyltransferase 1 | N-terminal Xaa-Pro-Lys N-methyltransferase 1, N-terminally processed | NRMT | NRMT1 | NRMT1 | NTM1A | NTM1A_HUMAN | NTMT1 | X-Pro-Lys N-terminal protein methyltransferase 1A | ||
| Type: | PROTEIN | ||
| Mol. Mass.: | 25382.72 | ||
| Organism: | Homo sapiens | ||
| Description: | ChEMBL_119192 | ||
| Residue: | 223 | ||
| Sequence: |
| ||
| BDBM50593134 | |||
| n/a | |||
| Name | BDBM50593134 | ||
| Synonyms: | CHEMBL5170768 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C23H29N3O4S | ||
| Mol. Mass. | 443.559 | ||
| SMILES | CC(C)(NC(=O)O[C@@H]1CN2CCC1CC2)c1csc(n1)-c1ccc(CCC(O)=O)cc1 |r,wU:7.6,(-4.96,3.4,;-4.96,1.86,;-3.63,2.63,;-6.5,1.86,;-7.27,3.19,;-6.5,4.53,;-8.81,3.19,;-9.58,1.86,;-11.12,1.86,;-11.89,.53,;-11.12,-.81,;-9.58,-.81,;-8.81,.53,;-10.16,1.24,;-10.56,-.24,;-4.19,.53,;-4.67,-.94,;-3.42,-1.84,;-2.18,-.94,;-2.65,.53,;-.69,-1.34,;.4,-.25,;1.88,-.65,;2.28,-2.13,;3.77,-2.53,;4.86,-1.44,;6.35,-1.84,;7.43,-.75,;6.75,-3.34,;1.2,-3.22,;-.29,-2.83,)| | ||
| Structure | 
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