| Reaction Details |
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 | Report a problem with these data |
| Target | Cysteine protease |
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| Ligand | BDBM50594412 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2212689 (CHEMBL5125638) |
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| Ki | 1.1±n/a nM |
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| Citation |  Previti, S; Ettari, R; Calcaterra, E; Di Chio, C; Ravichandran, R; Zimmer, C; Hammerschmidt, S; Wagner, A; Bogacz, M; Cosconati, S; Schirmeister, T; Zappalą, M Development of Urea-Bond-Containing Michael Acceptors as Antitrypanosomal Agents Targeting Rhodesain. ACS Med Chem Lett13:1083-1090 (2022) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cysteine protease |
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| Name: | Cysteine protease |
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| Synonyms: | Rhodesain |
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| Type: | PROTEIN |
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| Mol. Mass.: | 48425.78 |
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| Organism: | Trypanosoma brucei rhodesiense |
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| Description: | ChEMBL_619861 |
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| Residue: | 450 |
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| Sequence: | MPRTEMVRFVRLPVVLLAMAACLASVALGSLHVEESLEMRFAAFKKKYGKVYKDAKEEAF
RFRAFEENMEQAKIQAAANPYATFGVTPFSDMTREEFRARYRNGASYFAAAQKRLRKTVN
VTTGRAPAAVDWREKGAVTPVKDQGQCGSCWAFSTIGNIEGQWQVAGNPLVSLSEQMLVS
CDTIDFGCGGGLMDNAFNWIVNSNGGNVFTEASYPYVSGNGEQPQCQMNGHEIGAAITDH
VDLPQDEDAIAAYLAENGPLAIAVDATSFMDYNGGILTSCTSEQLDHGVLLVGYNDSSNP
PYWIIKNSWSNMWGEDGYIRIEKGTNQCLMNQAVSSAVVGGPTPPPPPPPPPSATFTQDF
CEGKGCTKGCSHATFPTGECVQTTGVGSVIATCGASNLTQIIYPLSRSCSGLSVPITVPL
DKCIPILIGSVEYHCSTNPPTKAARLVPHQ
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| BDBM50594412 |
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| n/a |
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| Name | BDBM50594412 |
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| Synonyms: | CHEMBL5175052 |
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| Type | Small organic molecule |
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| Emp. Form. | C30H33N3O4 |
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| Mol. Mass. | 499.6007 |
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| SMILES | COc1ccc(NC(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCc2ccccc2)\C=C\C(C)=O)cc1 |r| |
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| Structure | 
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