| Reaction Details |
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 | Report a problem with these data |
| Target | 11-beta-hydroxysteroid dehydrogenase 1 |
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| Ligand | BDBM50595155 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2215659 (CHEMBL5128791) |
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| IC50 | 40±n/a nM |
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| Citation |  Zhang, C; Xu, M; He, C; Zhuo, J; Burns, DM; Qian, DQ; Lin, Q; Li, YL; Chen, L; Shi, E; Agrios, C; Weng, L; Sharief, V; Jalluri, R; Li, Y; Scherle, P; Diamond, S; Hunter, D; Covington, M; Marando, C; Wynn, R; Katiyar, K; Contel, N; Vaddi, K; Yeleswaram, S; Hollis, G; Huber, R; Friedman, S; Metcalf, B; Yao, W Discovery of 1'-(1-phenylcyclopropane-carbonyl)-3H-spiro[isobenzofuran-1,3'-pyrrolidin]-3-one as a novel steroid mimetic scaffold for the potent and tissue-specific inhibition of 11?-HSD1 using a scaffold-hopping approach. Bioorg Med Chem Lett69:0 (2022) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| 11-beta-hydroxysteroid dehydrogenase 1 |
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| Name: | 11-beta-hydroxysteroid dehydrogenase 1 |
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| Synonyms: | 11-DH | 11-beta-HSD1 | 11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1) | 11-beta-hydroxysteroid dehydrogenase | 11-beta-hydroxysteroid dehydrogenase 1 (11HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD-1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11beta-HSD1) | DHI1_HUMAN | HSD11 | HSD11B1 | HSD11L | SDR26C1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 32409.16 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P28845 |
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| Residue: | 292 |
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| Sequence: | MAFMKKYLLPILGLFMAYYYYSANEEFRPEMLQGKKVIVTGASKGIGREMAYHLAKMGAH
VVVTARSKETLQKVVSHCLELGAASAHYIAGTMEDMTFAEQFVAQAGKLMGGLDMLILNH
ITNTSLNLFHDDIHHVRKSMEVNFLSYVVLTVAALPMLKQSNGSIVVVSSLAGKVAYPMV
AAYSASKFALDGFFSSIRKEYSVSRVNVSITLCVLGLIDTETAMKAVSGIVHMQAAPKEE
CALEIIKGGALRQEEVYYDSSLWTTLLIRNPCRKILEFLYSTSYNMDRFINK
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| BDBM50595155 |
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| n/a |
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| Name | BDBM50595155 |
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| Synonyms: | CHEMBL5191041 |
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| Type | Small organic molecule |
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| Emp. Form. | C28H25N3O4 |
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| Mol. Mass. | 467.5158 |
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| SMILES | CNC(=O)c1cccc(c1)-c1ccc(cn1)C1(CC1)C(=O)N1CC[C@@]2(C1)OC(=O)c1ccccc21 |r| |
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| Structure | 
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