| Reaction Details |
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 | Report a problem with these data |
| Target | Orexin receptor type 2 |
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| Ligand | BDBM50596326 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2220275 (CHEMBL5133609) |
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| EC50 | 23±n/a nM |
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| Citation |  Hino, T; Saitoh, T; Nagumo, Y; Yamamoto, N; Kutsumura, N; Irukayama-Tomobe, Y; Ishikawa, Y; Tanimura, R; Yanagisawa, M; Nagase, H Design and synthesis of novel orexin 2 receptor agonists based on naphthalene skeleton. Bioorg Med Chem Lett59:0 (2022) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Orexin receptor type 2 |
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| Name: | Orexin receptor type 2 |
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| Synonyms: | HCRTR2 | Hypocretin receptor type 2 | OX2R_HUMAN | Orexin receptor type 2 (OR 2) | Orexin receptor type 2 (OR-2) | Orexin receptor type 2 (OX2) | Orexin receptor type 2 (OX2R) | Orexin receptor type 2 (OxR2) | Ox-2-R | Ox2-R |
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| Type: | Protein |
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| Mol. Mass.: | 50710.53 |
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| Organism: | Homo sapiens (Human) |
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| Description: | O43614 |
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| Residue: | 444 |
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| Sequence: | MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAG
YIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETW
FFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVS
CIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMV
LAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARR
KTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAAN
PIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKL
SEQVVLTSISTLPAANGAGPLQNW
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| BDBM50596326 |
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| n/a |
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| Name | BDBM50596326 |
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| Synonyms: | CHEMBL5176007 |
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| Type | Small organic molecule |
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| Emp. Form. | C35H33N3O6S |
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| Mol. Mass. | 623.718 |
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| SMILES | COc1cccc(c1)C(=O)N(C)c1cccc2ccc(NS(=O)(=O)c3cc(ccc3OC)-c3cccc(c3)C(=O)N(C)C)cc12 |
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| Structure | 
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