| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Pyruvate kinase PKLR |
|---|
| Ligand | BDBM50143419 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_2222229 (CHEMBL5135563) |
|---|
| IC50 | 200±n/a nM |
|---|
| Citation |  Nain-Perez, A; Foller Füchtbauer, A; Hĺversen, L; Lulla, A; Gao, C; Matic, J; Monjas, L; Rodríguez, A; Brear, P; Kim, W; Hyvönen, M; Borén, J; Mardinoglu, A; Uhlen, M; Grřtli, M Anthraquinone derivatives as ADP-competitive inhibitors of liver pyruvate kinase. Eur J Med Chem234:0 (2022) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Pyruvate kinase PKLR |
|---|
| Name: | Pyruvate kinase PKLR |
|---|
| Synonyms: | KPYR_HUMAN | PK1 | PK1 | PKL | PKLR | Pyruvate kinase 1 | Pyruvate kinase PKLR | Pyruvate kinase isozymes L/R | R-type/L-type pyruvate kinase | Red cell/liver pyruvate kinase |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 61835.49 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_103054 |
|---|
| Residue: | 574 |
|---|
| Sequence: | MSIQENISSLQLRSWVSKSQRDLAKSILIGAPGGPAGYLRRASVAQLTQELGTAFFQQQQ
LPAAMADTFLEHLCLLDIDSEPVAARSTSIIATIGPASRSVERLKEMIKAGMNIARLNFS
HGSHEYHAESIANVREAVESFAGSPLSYRPVAIALDTKGPEIRTGILQGGPESEVELVKG
SQVLVTVDPAFRTRGNANTVWVDYPNIVRVVPVGGRIYIDDGLISLVVQKIGPEGLVTQV
ENGGVLGSRKGVNLPGAQVDLPGLSEQDVRDLRFGVEHGVDIVFASFVRKASDVAAVRAA
LGPEGHGIKIISKIENHEGVKRFDEILEVSDGIMVARGDLGIEIPAEKVFLAQKMMIGRC
NLAGKPVVCATQMLESMITKPRPTRAETSDVANAVLDGADCIMLSGETAKGNFPVEAVKM
QHAIAREAEAAVYHRQLFEELRRAAPLSRDPTEVTAIGAVEAAFKCCAAAIIVLTTTGRS
AQLLSRYRPRAAVIAVTRSAQAARQVHLCRGVFPLLYREPPEAIWADDVDRRVQFGIESG
KLRGFLRVGDLVIVVTGWRPGSGYTNIMRVLSIS
|
|
|
|---|
| BDBM50143419 |
|---|
| n/a |
|---|
| Name | BDBM50143419 |
|---|
| Synonyms: | CHEMBL175336 | Sodium; 3,4-dihydroxy-9,10-dioxo-9,10-dihydro-anthracene-2-sulfonate |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C14H7O7S |
|---|
| Mol. Mass. | 319.267 |
|---|
| SMILES | Oc1c(O)c2C(=O)c3ccccc3C(=O)c2cc1S([O-])(=O)=O |
|---|
| Structure | 
|
|---|
Search and Browse
