Reaction Details |
| Report a problem with these data |
Target | Renin |
---|
Ligand | BDBM50173082 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_321409 (CHEMBL880644) |
---|
IC50 | 450±n/a nM |
---|
Citation | Powell, NA; Clay, EH; Holsworth, DD; Bryant, JW; Ryan, MJ; Jalaie, M; Edmunds, JJ Benzyl ether structure-activity relationships in a series of ketopiperazine-based renin inhibitors. Bioorg Med Chem Lett15:4713-6 (2005) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Renin |
---|
Name: | Renin |
Synonyms: | Angiotensinogenase | REN | RENI_HUMAN |
Type: | Enzyme |
Mol. Mass.: | 45058.99 |
Organism: | Homo sapiens (Human) |
Description: | n/a |
Residue: | 406 |
Sequence: | MDGWRRMPRWGLLLLLWGSCTFGLPTDTTTFKRIFLKRMPSIRESLKERGVDMARLGPEW
SQPMKRLTLGNTTSSVILTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRL
YTACVYHKLFDASDSSSYKHNGTELTLRYSTGTVSGFLSQDIITVGGITVTQMFGEVTEM
PALPFMLAEFDGVVGMGFIEQAIGRVTPIFDNIISQGVLKEDVFSFYYNRDSENSQSLGG
QIVLGGSDPQHYEGNFHYINLIKTGVWQIQMKGVSVGSSTLLCEDGCLALVDTGASYISG
STSSIEKLMEALGAKKRLFDYVVKCNEGPTLPDISFHLGGKEYTLTSADYVFQESYSSKK
LCTLAIHAMDIPPPTGPTWALGATFIRKFYTEFDRRNNRIGFALAR
|
|
|
BDBM50173082 |
---|
n/a |
---|
Name | BDBM50173082 |
Synonyms: | (R)-6-(4-Fluoro-benzyloxymethyl)-1-{4-[3-(2-methoxy-benzyloxy)-propoxy]-phenyl}-piperazin-2-one | CHEMBL371193 |
Type | Small organic molecule |
Emp. Form. | C29H33FN2O5 |
Mol. Mass. | 508.5811 |
SMILES | COc1ccccc1COCCCOc1ccc(cc1)N1[C@@H](COCc2ccc(F)cc2)CNCC1=O |
Structure |
|