| Reaction Details |
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 | Report a problem with these data |
| Target | Dihydroorotate dehydrogenase (quinone), mitochondrial |
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| Ligand | BDBM14712 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_321227 (CHEMBL881227) |
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| IC50 | 156±n/a nM |
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| Citation |  Leban, J; Kralik, M; Mies, J; Gassen, M; Tentschert, K; Baumgartner, R SAR, species specificity, and cellular activity of cyclopentene dicarboxylic acid amides as DHODH inhibitors. Bioorg Med Chem Lett15:4854-7 (2005) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Dihydroorotate dehydrogenase (quinone), mitochondrial |
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| Name: | Dihydroorotate dehydrogenase (quinone), mitochondrial |
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| Synonyms: | Dhodh | Dihydroorotate dehydrogenase | PYRD_MOUSE |
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| Type: | PROTEIN |
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| Mol. Mass.: | 42711.08 |
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| Organism: | Mus musculus |
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| Description: | ChEMBL_1366444 |
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| Residue: | 395 |
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| Sequence: | MAWRQLRKRALDAAIILGGGGLLFTSYLTATGDDHFYAEYLMPALQRLLDPESAHRLAVR
VISLGLLPRATFQDSNMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKLGFGFVEVGSV
TPQPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSAVEHRLRARQQKQTQLTTDGLPLGIN
LGKNKTSVDAAADYVEGVRILGPLADYLVVNVSSPNTAGLRSLQGKTELRRLLSKVLQER
DALKGPQKPAVLVKIAPDLTAQDKEDIASVARELGIDGLIITNTTVSRPVGLQGALRSET
GGLSGKPLRDLSTQTIREMYALTQGTIPIIGVGGVSSGQDALEKIQAGASLVQLYTALTF
LGPPVVARVKRELEALLKERGFNTVTDAIGVDHRR
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| BDBM14712 |
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| n/a |
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| Name | BDBM14712 |
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| Synonyms: | (2Z)-2-cyano-3-hydroxy-N-[4-(trifluoromethyl)phenyl]but-2-enamide | A77 1726 | CHEMBL973 | CHEMBL999 | TERIFLUNOMIDE |
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| Type | Small organic molecule |
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| Emp. Form. | C12H9F3N2O2 |
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| Mol. Mass. | 270.2073 |
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| SMILES | CC(=O)C(C#N)C(=O)Nc1ccc(cc1)C(F)(F)F |
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| Structure | 
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