| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Dihydroorotate dehydrogenase (quinone), mitochondrial |
|---|
| Ligand | BDBM14712 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_321456 (CHEMBL879486) |
|---|
| IC50 | 420±n/a nM |
|---|
| Citation |  Leban, J; Kralik, M; Mies, J; Gassen, M; Tentschert, K; Baumgartner, R SAR, species specificity, and cellular activity of cyclopentene dicarboxylic acid amides as DHODH inhibitors. Bioorg Med Chem Lett15:4854-7 (2005) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Dihydroorotate dehydrogenase (quinone), mitochondrial |
|---|
| Name: | Dihydroorotate dehydrogenase (quinone), mitochondrial |
|---|
| Synonyms: | DHODH | DHOdehase | Dihydroorotate dehydrogenase | Dihydroorotate dehydrogenase (DHODH) | Dihydroorotate dehydrogenase, mitochondrial | Dihydroorotate oxidase | Dihydroorotate oxidase (DHODH) | PYRD_HUMAN |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 42881.33 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q02127 |
|---|
| Residue: | 395 |
|---|
| Sequence: | MAWRHLKKRAQDAVIILGGGGLLFASYLMATGDERFYAEHLMPTLQGLLDPESAHRLAVR
FTSLGLLPRARFQDSDMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKMGFGFVEIGSV
TPKPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAKLTEDGLPLGVN
LGKNKTSVDAAEDYAEGVRVLGPLADYLVVNVSSPNTAGLRSLQGKAELRRLLTKVLQER
DGLRRVHRPAVLVKIAPDLTSQDKEDIASVVKELGIDGLIVTNTTVSRPAGLQGALRSET
GGLSGKPLRDLSTQTIREMYALTQGRVPIIGVGGVSSGQDALEKIRAGASLVQLYTALTF
WGPPVVGKVKRELEALLKEQGFGGVTDAIGADHRR
|
|
|
|---|
| BDBM14712 |
|---|
| n/a |
|---|
| Name | BDBM14712 |
|---|
| Synonyms: | (2Z)-2-cyano-3-hydroxy-N-[4-(trifluoromethyl)phenyl]but-2-enamide | A77 1726 | CHEMBL973 | CHEMBL999 | TERIFLUNOMIDE |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C12H9F3N2O2 |
|---|
| Mol. Mass. | 270.2073 |
|---|
| SMILES | CC(=O)C(C#N)C(=O)Nc1ccc(cc1)C(F)(F)F |
|---|
| Structure | 
|
|---|
Search and Browse
