| Reaction Details |
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 | Report a problem with these data |
| Target | Toll-like receptor 7 |
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| Ligand | BDBM443891 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2222656 (CHEMBL5135990) |
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| IC50 | 57±n/a nM |
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| Citation |  Sreekantha, RK; Mussari, CP; Dodd, DS; Pasunoori, L; Hegde, S; Posy, SL; Critton, D; Ruepp, S; Subramanian, M; Salter-Cid, LM; Tagore, DM; Sarodaya, S; Dudhgaonkar, S; Poss, MA; Schieven, GL; Carter, PH; Macor, JE; Dyckman, AJ Identification of 2-Pyridinylindole-Based Dual Antagonists of Toll-like Receptors 7 and 8 (TLR7/8). ACS Med Chem Lett13:812-818 (2022) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Toll-like receptor 7 |
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| Name: | Toll-like receptor 7 |
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| Synonyms: | ORF Names:UNQ248/PRO285 | TLR7 | TLR7_HUMAN | Toll-like receptor 7 (TLR7) |
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| Type: | Enzyme |
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| Mol. Mass.: | 120945.35 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9NYK1 |
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| Residue: | 1049 |
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| Sequence: | MVFPMWTLKRQILILFNIILISKLLGARWFPKTLPCDVTLDVPKNHVIVDCTDKHLTEIP
GGIPTNTTNLTLTINHIPDISPASFHRLDHLVEIDFRCNCVPIPLGSKNNMCIKRLQIKP
RSFSGLTYLKSLYLDGNQLLEIPQGLPPSLQLLSLEANNIFSIRKENLTELANIEILYLG
QNCYYRNPCYVSYSIEKDAFLNLTKLKVLSLKDNNVTAVPTVLPSTLTELYLYNNMIAKI
QEDDFNNLNQLQILDLSGNCPRCYNAPFPCAPCKNNSPLQIPVNAFDALTELKVLRLHSN
SLQHVPPRWFKNINKLQELDLSQNFLAKEIGDAKFLHFLPSLIQLDLSFNFELQVYRASM
NLSQAFSSLKSLKILRIRGYVFKELKSFNLSPLHNLQNLEVLDLGTNFIKIANLSMFKQF
KRLKVIDLSVNKISPSGDSSEVGFCSNARTSVESYEPQVLEQLHYFRYDKYARSCRFKNK
EASFMSVNESCYKYGQTLDLSKNSIFFVKSSDFQHLSFLKCLNLSGNLISQTLNGSEFQP
LAELRYLDFSNNRLDLLHSTAFEELHKLEVLDISSNSHYFQSEGITHMLNFTKNLKVLQK
LMMNDNDISSSTSRTMESESLRTLEFRGNHLDVLWREGDNRYLQLFKNLLKLEELDISKN
SLSFLPSGVFDGMPPNLKNLSLAKNGLKSFSWKKLQCLKNLETLDLSHNQLTTVPERLSN
CSRSLKNLILKNNQIRSLTKYFLQDAFQLRYLDLSSNKIQMIQKTSFPENVLNNLKMLLL
HHNRFLCTCDAVWFVWWVNHTEVTIPYLATDVTCVGPGAHKGQSVISLDLYTCELDLTNL
ILFSLSISVSLFLMVMMTASHLYFWDVWYIYHFCKAKIKGYQRLISPDCCYDAFIVYDTK
DPAVTEWVLAELVAKLEDPREKHFNLCLEERDWLPGQPVLENLSQSIQLSKKTVFVMTDK
YAKTENFKIAFYLSHQRLMDEKVDVIILIFLEKPFQKSKFLQLRKRLCGSSVLEWPTNPQ
AHPYFWQCLKNALATDNHVAYSQVFKETV
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| BDBM443891 |
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| n/a |
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| Name | BDBM443891 |
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| Synonyms: | 2-(2-ethyl-6-methylpyridin-4-yl)-3-isopropyl-5-(piperidin-4-yl)-1H-indole | US10660877, Example 479 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H31N3 |
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| Mol. Mass. | 361.523 |
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| SMILES | CCc1cc(cc(C)n1)-c1[nH]c2ccc(cc2c1C(C)C)C1CCNCC1 |
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| Structure | 
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