| Reaction Details |
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 | Report a problem with these data |
| Target | Toll-like receptor 3 |
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| Ligand | BDBM21958 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2222660 (CHEMBL5135994) |
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| IC50 | >10000±n/a nM |
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| Citation |  Sreekantha, RK; Mussari, CP; Dodd, DS; Pasunoori, L; Hegde, S; Posy, SL; Critton, D; Ruepp, S; Subramanian, M; Salter-Cid, LM; Tagore, DM; Sarodaya, S; Dudhgaonkar, S; Poss, MA; Schieven, GL; Carter, PH; Macor, JE; Dyckman, AJ Identification of 2-Pyridinylindole-Based Dual Antagonists of Toll-like Receptors 7 and 8 (TLR7/8). ACS Med Chem Lett13:812-818 (2022) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Toll-like receptor 3 |
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| Name: | Toll-like receptor 3 |
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| Synonyms: | CD_antigen=CD283 | TLR3 | TLR3_HUMAN | Toll-like receptor 3 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 103839.45 |
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| Organism: | Homo sapiens |
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| Description: | ChEMBL_117752 |
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| Residue: | 904 |
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| Sequence: | MRQTLPCIYFWGGLLPFGMLCASSTTKCTVSHEVADCSHLKLTQVPDDLPTNITVLNLTH
NQLRRLPAANFTRYSQLTSLDVGFNTISKLEPELCQKLPMLKVLNLQHNELSQLSDKTFA
FCTNLTELHLMSNSIQKIKNNPFVKQKNLITLDLSHNGLSSTKLGTQVQLENLQELLLSN
NKIQALKSEELDIFANSSLKKLELSSNQIKEFSPGCFHAIGRLFGLFLNNVQLGPSLTEK
LCLELANTSIRNLSLSNSQLSTTSNTTFLGLKWTNLTMLDLSYNNLNVVGNDSFAWLPQL
EYFFLEYNNIQHLFSHSLHGLFNVRYLNLKRSFTKQSISLASLPKIDDFSFQWLKCLEHL
NMEDNDIPGIKSNMFTGLINLKYLSLSNSFTSLRTLTNETFVSLAHSPLHILNLTKNKIS
KIESDAFSWLGHLEVLDLGLNEIGQELTGQEWRGLENIFEIYLSYNKYLQLTRNSFALVP
SLQRLMLRRVALKNVDSSPSPFQPLRNLTILDLSNNNIANINDDMLEGLEKLEILDLQHN
NLARLWKHANPGGPIYFLKGLSHLHILNLESNGFDEIPVEVFKDLFELKIIDLGLNNLNT
LPASVFNNQVSLKSLNLQKNLITSVEKKVFGPAFRNLTELDMRFNPFDCTCESIAWFVNW
INETHTNIPELSSHYLCNTPPHYHGFPVRLFDTSSCKDSAPFELFFMINTSILLIFIFIV
LLIHFEGWRISFYWNVSVHRVLGFKEIDRQTEQFEYAAYIIHAYKDKDWVWEHFSSMEKE
DQSLKFCLEERDFEAGVFELEAIVNSIKRSRKIIFVITHHLLKDPLCKRFKVHHAVQQAI
EQNLDSIILVFLEEIPDYKLNHALCLRRGMFKSHCILNWPVQKERIGAFRHKLQVALGSK
NSVH
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| BDBM21958 |
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| n/a |
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| Name | BDBM21958 |
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| Synonyms: | 2-(2,6-dimethylpyridin-4-yl)-3-isopropyl-5-(piperidin-4-yl)-1H-indole Hydrochloride | US10660877, Example 1 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H29N3 |
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| Mol. Mass. | 347.4965 |
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| SMILES | CC(C)c1c([nH]c2ccc(cc12)C1CCNCC1)-c1cc(C)nc(C)c1 |
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| Structure | 
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