| Reaction Details |
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 | Report a problem with these data |
| Target | Cathepsin S |
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| Ligand | BDBM50240981 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_321238 (CHEMBL881773) |
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| IC50 | >10000±n/a nM |
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| Citation |  Black, WC; Bayly, CI; Davis, DE; Desmarais, S; Falgueyret, JP; Léger, S; Li, CS; Massé, F; McKay, DJ; Palmer, JT; Percival, MD; Robichaud, J; Tsou, N; Zamboni, R Trifluoroethylamines as amide isosteres in inhibitors of cathepsin K. Bioorg Med Chem Lett15:4741-4 (2005) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cathepsin S |
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| Name: | Cathepsin S |
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| Synonyms: | CATS_HUMAN | CTSS | Cathepsin S (Cat S) | cathepsin S preproprotein |
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| Type: | Protein |
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| Mol. Mass.: | 37507.38 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P25774 |
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| Residue: | 331 |
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| Sequence: | MKRLVCVLLVCSSAVAQLHKDPTLDHHWHLWKKTYGKQYKEKNEEAVRRLIWEKNLKFVM
LHNLEHSMGMHSYDLGMNHLGDMTSEEVMSLMSSLRVPSQWQRNITYKSNPNRILPDSVD
WREKGCVTEVKYQGSCGACWAFSAVGALEAQLKLKTGKLVSLSAQNLVDCSTEKYGNKGC
NGGFMTTAFQYIIDNKGIDSDASYPYKAMDQKCQYDSKYRAATCSKYTELPYGREDVLKE
AVANKGPVSVGVDARHPSFFLYRSGVYYEPSCTQNVNHGVLVVGYGDLNGKEYWLVKNSW
GHNFGEEGYIRMARNKGNHCGIASFPSYPEI
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| BDBM50240981 |
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| n/a |
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| Name | BDBM50240981 |
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| Synonyms: | 4'-piperazin-1-yl-biphenyl-4-carboxylic acid [1-(cyanomethyl-carbamoyl)-cyclohexyl]-amide | CHEMBL371133 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H31N5O2 |
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| Mol. Mass. | 445.5566 |
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| SMILES | O=C(NC1(CCCCC1)C(=O)NCC#N)c1ccc(cc1)-c1ccc(cc1)N1CCNCC1 |
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| Structure | 
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