Ki Summary

Reaction Details

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Target

Calcitonin gene-related peptide type 1 receptor

Ligand

BDBM50173468

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_321551 (CHEMBL881965)

7.4±n/a

IC50

6.4±n/a nM

Comments

extracted

Citation

Rudolf, K; Eberlein, W; Engel, W; Pieper, H; Entzeroth, M; Hallermayer, G; Doods, H Development of human calcitonin gene-related peptide (CGRP) receptor antagonists. 1. Potent and selective small molecule CGRP antagonists. 1-[N2-[3,5-dibromo-N-[[4-(3,4-dihydro-2(1H)-oxoquinazolin-3-yl)-1-piperidinyl]carbonyl]-D-tyrosyl]-l-lysyl]-4-(4-pyridinyl)piperazine: the first CGRP antagonist J Med Chem48:5921-31 (2005) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Calcitonin gene-related peptide type 1 receptor

Name:

Calcitonin gene-related peptide type 1 receptor

Synonyms:

CALRL_RAT | Calcitonin-gene-related peptide receptor; CALCRL/RAMP1 | Calcrl | Cgrpr

Type:

PROTEIN

Mol. Mass.:

53330.91

Organism:

Rattus norvegicus

Description:

ChEMBL_1457286

Residue:

464

Sequence:

MMDKKCTLCFLFLLLLNMALIAAESEEGANQTDLGVTRNKIMTAQYECYQKIMQDPIQQG
EGLYCNRTWDGWLCWNDVAAGTESMQYCPDYFQDFDPSEKVTKICDQDGNWFRHPDSNRT
WTNYTLCNNSTHEKVKTALNLFYLTIIGHGLSIASLIISLIIFFYFKSLSCQRITLHKNL
FFSFVCNSIVTIIHLTAVANNQALVATNPVSCKVSQFIHLYLMGCNYFWMLCEGIYLHTL
IVVAVFAEKQHLMWYYFLGWGFPLLPACIHAIARSLYYNDNCWISSDTHLLYIIHGPICA
ALLVNLFFLLNIVRVLITKLKVTHQAESNLYMKAVRATLILVPLLGIEFVLFPWRPEGKV
AEEVYDYVMHILMHYQGLLVSTIFCFFNGEVQAILRRNWNQYKIQFGNGFSHSDALRSAS
YTVSTISDVQGYSHDCPTEHLNGKSIQDIENVALKPEKMYDLVM

BDBM50173468

n/a

Name

BDBM50173468

Synonyms:

4-(2-Oxo-1,4-dihydro-2H-quinazolin-3-yl)-piperidine-1-carboxylic acid [(S)-1-[(R)-5-amino-1-(4-pyridin-4-yl-piperazine-1-carbonyl)-pentylcarbamoyl]-2-(3,5-dibromo-4-hydroxy-phenyl)-ethyl]-amide | CHEMBL197529

Type

Small organic molecule

Emp. Form.

C38H47Br2N9O5

Mol. Mass.

869.645

SMILES

NCCCC[C@@H](NC(=O)[C@H](Cc1cc(Br)c(O)c(Br)c1)NC(=O)N1CCC(CC1)N1Cc2ccccc2NC1=O)C(=O)N1CCN(CC1)c1ccncc1

Structure